Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury
Aim: Patients with chronic mild or moderate traumatic brain injury have some regions of brain atrophy (including cerebral white matter) but even more regions of abnormal brain enlargement (including other cerebral regions). Hypothesis: Ipsilateral injury and atrophy cause the eventual development of...
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| Format: | Article |
| Language: | English |
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Aldus Press
2023-03-01
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| Series: | Concussion |
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| Online Access: | https://www.futuremedicine.com/doi/10.2217/cnc-2022-0003 |
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| author | David E Ross John D Seabaugh Jan M Seabaugh Claudia Alvarez Laura Peyton Ellis Christopher Powell Christopher Reese Leah Cooper Katherine Shepherd for the Alzheimer's Disease Neuroimaging Initiative |
| author_facet | David E Ross John D Seabaugh Jan M Seabaugh Claudia Alvarez Laura Peyton Ellis Christopher Powell Christopher Reese Leah Cooper Katherine Shepherd for the Alzheimer's Disease Neuroimaging Initiative |
| author_sort | David E Ross |
| collection | DOAJ |
| description | Aim: Patients with chronic mild or moderate traumatic brain injury have some regions of brain atrophy (including cerebral white matter) but even more regions of abnormal brain enlargement (including other cerebral regions). Hypothesis: Ipsilateral injury and atrophy cause the eventual development of contralateral compensatory hypertrophy. Materials & methods: 50 patients with mild or moderate traumatic brain injury were compared to 80 normal controls (n = 80) with respect to MRI brain volume asymmetry. Asymmetry-based correlations were used to test the primary hypothesis. Results: The group of patients had multiple regions of abnormal asymmetry. Conclusion: The correlational analyses supported the conclusion that acute injury to ipsilateral cerebral white matter regions caused atrophy, leading eventually to abnormal enlargement of contralateral regions due to compensatory hypertrophy. |
| format | Article |
| id | doaj-art-2fbb956bc0f84517872bb5afb7698fa3 |
| institution | DOAJ |
| issn | 2056-3299 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Aldus Press |
| record_format | Article |
| series | Concussion |
| spelling | doaj-art-2fbb956bc0f84517872bb5afb7698fa32025-08-20T03:20:24ZengAldus PressConcussion2056-32992023-03-018110.2217/cnc-2022-0003Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injuryDavid E Ross0John D Seabaugh1Jan M Seabaugh2Claudia Alvarez3Laura Peyton Ellis4Christopher Powell5Christopher Reese6Leah Cooper7Katherine Shepherd8for the Alzheimer's Disease Neuroimaging Initiative1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA1Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USAAim: Patients with chronic mild or moderate traumatic brain injury have some regions of brain atrophy (including cerebral white matter) but even more regions of abnormal brain enlargement (including other cerebral regions). Hypothesis: Ipsilateral injury and atrophy cause the eventual development of contralateral compensatory hypertrophy. Materials & methods: 50 patients with mild or moderate traumatic brain injury were compared to 80 normal controls (n = 80) with respect to MRI brain volume asymmetry. Asymmetry-based correlations were used to test the primary hypothesis. Results: The group of patients had multiple regions of abnormal asymmetry. Conclusion: The correlational analyses supported the conclusion that acute injury to ipsilateral cerebral white matter regions caused atrophy, leading eventually to abnormal enlargement of contralateral regions due to compensatory hypertrophy.https://www.futuremedicine.com/doi/10.2217/cnc-2022-0003asymmetryMRINeuroGage®NeuroQuant®traumatic brain injury (TBI)volumetry |
| spellingShingle | David E Ross John D Seabaugh Jan M Seabaugh Claudia Alvarez Laura Peyton Ellis Christopher Powell Christopher Reese Leah Cooper Katherine Shepherd for the Alzheimer's Disease Neuroimaging Initiative Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury Concussion asymmetry MRI NeuroGage® NeuroQuant® traumatic brain injury (TBI) volumetry |
| title | Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury |
| title_full | Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury |
| title_fullStr | Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury |
| title_full_unstemmed | Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury |
| title_short | Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury |
| title_sort | journey to the other side of the brain asymmetry in patients with chronic mild or moderate traumatic brain injury |
| topic | asymmetry MRI NeuroGage® NeuroQuant® traumatic brain injury (TBI) volumetry |
| url | https://www.futuremedicine.com/doi/10.2217/cnc-2022-0003 |
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