The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
The therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of “core” transcription factors for maintaining the stem cell state. I...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/4829602 |
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| _version_ | 1849693467044741120 |
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| author | Alastair H. Davies Amina Zoubeidi |
| author_facet | Alastair H. Davies Amina Zoubeidi |
| author_sort | Alastair H. Davies |
| collection | DOAJ |
| description | The therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of “core” transcription factors for maintaining the stem cell state. It is now clear that stem cell regulatory networks are far more complex. In this review, we examine the role of the androgen receptor (AR) in coordinating interactions between signaling nodes that govern the balance of cell fate decisions in prostate stem cells. |
| format | Article |
| id | doaj-art-2fbafdc1a3244d069e209ed33d655b8a |
| institution | DOAJ |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2fbafdc1a3244d069e209ed33d655b8a2025-08-20T03:20:24ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/48296024829602The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem CellsAlastair H. Davies0Amina Zoubeidi1Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, CanadaVancouver Prostate Centre, Vancouver, BC, V6H 3Z6, CanadaThe therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of “core” transcription factors for maintaining the stem cell state. It is now clear that stem cell regulatory networks are far more complex. In this review, we examine the role of the androgen receptor (AR) in coordinating interactions between signaling nodes that govern the balance of cell fate decisions in prostate stem cells.http://dx.doi.org/10.1155/2016/4829602 |
| spellingShingle | Alastair H. Davies Amina Zoubeidi The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells Stem Cells International |
| title | The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells |
| title_full | The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells |
| title_fullStr | The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells |
| title_full_unstemmed | The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells |
| title_short | The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells |
| title_sort | androgen receptor bridges stem cell associated signaling nodes in prostate stem cells |
| url | http://dx.doi.org/10.1155/2016/4829602 |
| work_keys_str_mv | AT alastairhdavies theandrogenreceptorbridgesstemcellassociatedsignalingnodesinprostatestemcells AT aminazoubeidi theandrogenreceptorbridgesstemcellassociatedsignalingnodesinprostatestemcells AT alastairhdavies androgenreceptorbridgesstemcellassociatedsignalingnodesinprostatestemcells AT aminazoubeidi androgenreceptorbridgesstemcellassociatedsignalingnodesinprostatestemcells |