Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes
Classical knowledge about the pathogenesis of diabetes and its complications in recent years has been supplemented by ideas about the role of chronic inflammation. It has been established that inflammatory reactions play a role in the beta cell dysfunction, the formation of insulin resistance and re...
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Russian Academy of Sciences, Siberian Branch Publishing House
2024-04-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/1455 |
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| author | V. V. Klimontov К. R. Mavlianov |
| author_facet | V. V. Klimontov К. R. Mavlianov |
| author_sort | V. V. Klimontov |
| collection | DOAJ |
| description | Classical knowledge about the pathogenesis of diabetes and its complications in recent years has been supplemented by ideas about the role of chronic inflammation. It has been established that inflammatory reactions play a role in the beta cell dysfunction, the formation of insulin resistance and remodeling of the vascular wall. Cytokines, soluble low molecular weight proteins and peptides that perform informational and regulatory functions, play central role in the development of inflammation. A wide range of biological activity and involvement in many aspects of pathogenesis make it possible to consider cytokines as promising molecules for diagnosing and predicting the complications. In this review, we summarize data from studies that assessed the role of cytokines as diagnostic and prognostic markers for the development of microvascular diabetic complications. Current data indicate that angiogenic and pro-inflammatory cytokines (VEGF, TNF-α, IL-6, IL-8, IL-15, IL-17, MCP-1, IP-10, INF-γ, PEDF, etc.) are promising biomarkers for proliferative diabetic retinopathy, especially when their local production is assessed (in vitreous, aqueous humor and tears). The role of these molecules as biomarkers of non-proliferative diabetic retinopathy and diabetic macular edema needs further research. Serum proinflammatory and fibrogenic cytokines (primarily MCP-1, IL-6, TNF-α, YKL-40, TGF-β and bFGF) and cytokine receptors (sTNFR1, sTNFR2) are considered as promising diagnostic and prognostic markers of diabetic kidney disease. Urinary excretion of IL-6 and MCP-1 turned out to be a predictor of the progression of diabetic nephropathy. Multi-bead assay and mass spectrometry make it possible to study cytokine panels in small samples of biological material. Combined biomarkers, including several cytokines, may increase the reliability of the prognosis of diabetic complications. |
| format | Article |
| id | doaj-art-2fb916fd9cbe4de38f4640a189a12e3a |
| institution | Kabale University |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| publishDate | 2024-04-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj-art-2fb916fd9cbe4de38f4640a189a12e3a2025-08-20T03:50:44ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202024-04-01442192710.18699/SSMJ20240202607Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetesV. V. Klimontov0К. R. Mavlianov1Research Institute of Clinical and Experimental Lymphology – Branch of the Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of the Federal Research Center Institute of Cytology and Genetics of SB RASClassical knowledge about the pathogenesis of diabetes and its complications in recent years has been supplemented by ideas about the role of chronic inflammation. It has been established that inflammatory reactions play a role in the beta cell dysfunction, the formation of insulin resistance and remodeling of the vascular wall. Cytokines, soluble low molecular weight proteins and peptides that perform informational and regulatory functions, play central role in the development of inflammation. A wide range of biological activity and involvement in many aspects of pathogenesis make it possible to consider cytokines as promising molecules for diagnosing and predicting the complications. In this review, we summarize data from studies that assessed the role of cytokines as diagnostic and prognostic markers for the development of microvascular diabetic complications. Current data indicate that angiogenic and pro-inflammatory cytokines (VEGF, TNF-α, IL-6, IL-8, IL-15, IL-17, MCP-1, IP-10, INF-γ, PEDF, etc.) are promising biomarkers for proliferative diabetic retinopathy, especially when their local production is assessed (in vitreous, aqueous humor and tears). The role of these molecules as biomarkers of non-proliferative diabetic retinopathy and diabetic macular edema needs further research. Serum proinflammatory and fibrogenic cytokines (primarily MCP-1, IL-6, TNF-α, YKL-40, TGF-β and bFGF) and cytokine receptors (sTNFR1, sTNFR2) are considered as promising diagnostic and prognostic markers of diabetic kidney disease. Urinary excretion of IL-6 and MCP-1 turned out to be a predictor of the progression of diabetic nephropathy. Multi-bead assay and mass spectrometry make it possible to study cytokine panels in small samples of biological material. Combined biomarkers, including several cytokines, may increase the reliability of the prognosis of diabetic complications.https://sibmed.elpub.ru/jour/article/view/1455diabetes mellitusdiabetic retinopathydiabetic nephropathychronic kidney diseasebiomarkercytokineinflammationgrowth factorinterleukin |
| spellingShingle | V. V. Klimontov К. R. Mavlianov Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes Сибирский научный медицинский журнал diabetes mellitus diabetic retinopathy diabetic nephropathy chronic kidney disease biomarker cytokine inflammation growth factor interleukin |
| title | Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes |
| title_full | Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes |
| title_fullStr | Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes |
| title_full_unstemmed | Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes |
| title_short | Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes |
| title_sort | сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes |
| topic | diabetes mellitus diabetic retinopathy diabetic nephropathy chronic kidney disease biomarker cytokine inflammation growth factor interleukin |
| url | https://sibmed.elpub.ru/jour/article/view/1455 |
| work_keys_str_mv | AT vvklimontov sytokinesaspromisingdiagnosticandprognosticbiomarkersofmicrovascularcomplicationsofdiabetes AT krmavlianov sytokinesaspromisingdiagnosticandprognosticbiomarkersofmicrovascularcomplicationsofdiabetes |