Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity
Bromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone (4) yielded (5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine [6(a-g)]. However reaction of (5) with 4-chloro-2-triflouro acetyl...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/361282 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693466565541888 |
|---|---|
| author | Md Salahuddin Sunil Kakad S. M. Shantakumar |
| author_facet | Md Salahuddin Sunil Kakad S. M. Shantakumar |
| author_sort | Md Salahuddin |
| collection | DOAJ |
| description | Bromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone (4) yielded (5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine [6(a-g)]. However reaction of (5) with 4-chloro-2-triflouro acetyl aniline provided (6h). Similarly reaction of (5) with 5-amino tetrazole & 2-amino benzimidazole produced (6i) & (6j) respectively. All the synthesized compounds were tested against bacteria (Gram positive and Gram negative). |
| format | Article |
| id | doaj-art-2fb7cd3b662d44ec841f84d4a4253418 |
| institution | DOAJ |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-2fb7cd3b662d44ec841f84d4a42534182025-08-20T03:20:24ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016380180810.1155/2009/361282Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial ActivityMd Salahuddin0Sunil Kakad1S. M. Shantakumar2Department of Pharmaceutical Chemistry, V.L.College of Pharmacy, Raichur-584103, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, V.L.College of Pharmacy, Raichur-584103, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, V.L.College of Pharmacy, Raichur-584103, Karnataka, IndiaBromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone (4) yielded (5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine [6(a-g)]. However reaction of (5) with 4-chloro-2-triflouro acetyl aniline provided (6h). Similarly reaction of (5) with 5-amino tetrazole & 2-amino benzimidazole produced (6i) & (6j) respectively. All the synthesized compounds were tested against bacteria (Gram positive and Gram negative).http://dx.doi.org/10.1155/2009/361282 |
| spellingShingle | Md Salahuddin Sunil Kakad S. M. Shantakumar Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity E-Journal of Chemistry |
| title | Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity |
| title_full | Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity |
| title_fullStr | Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity |
| title_full_unstemmed | Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity |
| title_short | Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity |
| title_sort | synthesis of some novel thieno 2 3 d pyrimidines and their antibacterial activity |
| url | http://dx.doi.org/10.1155/2009/361282 |
| work_keys_str_mv | AT mdsalahuddin synthesisofsomenovelthieno23dpyrimidinesandtheirantibacterialactivity AT sunilkakad synthesisofsomenovelthieno23dpyrimidinesandtheirantibacterialactivity AT smshantakumar synthesisofsomenovelthieno23dpyrimidinesandtheirantibacterialactivity |