The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency
ABSTRACT Background Premature ovarian insufficiency (POI) is a condition in women characterized by the premature decline of ovarian function before age 40, evident through menstrual irregularities such as amenorrhea or oligomenorrhea, elevated FSH levels exceeding 25 U/L, and a progressive decrease...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.70074 |
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| author | Hui Gao Xi‐Xia Cao Hua Hua Hui Zhu |
| author_facet | Hui Gao Xi‐Xia Cao Hua Hua Hui Zhu |
| author_sort | Hui Gao |
| collection | DOAJ |
| description | ABSTRACT Background Premature ovarian insufficiency (POI) is a condition in women characterized by the premature decline of ovarian function before age 40, evident through menstrual irregularities such as amenorrhea or oligomenorrhea, elevated FSH levels exceeding 25 U/L, and a progressive decrease in estrogen levels. Despite considerable research, the exact pathogenic mechanisms underlying POI remain unclear. This study focuses on the role of microRNAs (miRNAs) in the development of POI. As critical regulators of gene expression, miRNAs may play significant roles in diagnosis and the development of innovative therapeutic approaches for POI. Methods A comprehensive literature search was conducted on PubMed for this review. We included studies published in English up to September 2024. Our search utilized a combination of the following keywords: microRNA, premature ovarian insufficiency (POI), and premature ovarian failure (POF). Articles were filtered by title and subsequently through full‐text review, selecting only those pertinent to our topics of interest and their related areas. Results miRNAs have emerged as critical regulators in POI, mediating a range of biological processes that contribute to the disease's progression. Their involvement offers promising insights for early diagnosis, prognostic assessments, and therapeutic interventions, highlighting their potential as biomarkers and therapeutic targets. Conclusion Elucidating miRNAs' roles in POI opens new avenues for managing the disease. By understanding how miRNAs influence the molecular mechanisms of POI, innovative strategies can be developed for diagnosis and treatment, potentially improving patient outcomes. |
| format | Article |
| id | doaj-art-2fb675dec42b42cbb10555cca98f4afb |
| institution | OA Journals |
| issn | 2324-9269 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj-art-2fb675dec42b42cbb10555cca98f4afb2025-08-20T02:01:19ZengWileyMolecular Genetics & Genomic Medicine2324-92692025-02-01132n/an/a10.1002/mgg3.70074The Functions and Implications of MicroRNAs in Premature Ovarian InsufficiencyHui Gao0Xi‐Xia Cao1Hua Hua2Hui Zhu3Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing ChinaDepartment of Reproductive Health, Nanjing Maternity and Child Health Care Hospital The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing ChinaDepartment of Reproductive Health, Nanjing Maternity and Child Health Care Hospital The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing ChinaDepartment of Reproductive Health, Nanjing Maternity and Child Health Care Hospital The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing ChinaABSTRACT Background Premature ovarian insufficiency (POI) is a condition in women characterized by the premature decline of ovarian function before age 40, evident through menstrual irregularities such as amenorrhea or oligomenorrhea, elevated FSH levels exceeding 25 U/L, and a progressive decrease in estrogen levels. Despite considerable research, the exact pathogenic mechanisms underlying POI remain unclear. This study focuses on the role of microRNAs (miRNAs) in the development of POI. As critical regulators of gene expression, miRNAs may play significant roles in diagnosis and the development of innovative therapeutic approaches for POI. Methods A comprehensive literature search was conducted on PubMed for this review. We included studies published in English up to September 2024. Our search utilized a combination of the following keywords: microRNA, premature ovarian insufficiency (POI), and premature ovarian failure (POF). Articles were filtered by title and subsequently through full‐text review, selecting only those pertinent to our topics of interest and their related areas. Results miRNAs have emerged as critical regulators in POI, mediating a range of biological processes that contribute to the disease's progression. Their involvement offers promising insights for early diagnosis, prognostic assessments, and therapeutic interventions, highlighting their potential as biomarkers and therapeutic targets. Conclusion Elucidating miRNAs' roles in POI opens new avenues for managing the disease. By understanding how miRNAs influence the molecular mechanisms of POI, innovative strategies can be developed for diagnosis and treatment, potentially improving patient outcomes.https://doi.org/10.1002/mgg3.70074microRNApremature ovarian failurepremature ovarian insufficiency |
| spellingShingle | Hui Gao Xi‐Xia Cao Hua Hua Hui Zhu The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency Molecular Genetics & Genomic Medicine microRNA premature ovarian failure premature ovarian insufficiency |
| title | The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency |
| title_full | The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency |
| title_fullStr | The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency |
| title_full_unstemmed | The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency |
| title_short | The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency |
| title_sort | functions and implications of micrornas in premature ovarian insufficiency |
| topic | microRNA premature ovarian failure premature ovarian insufficiency |
| url | https://doi.org/10.1002/mgg3.70074 |
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