To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants
Abstract In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize th...
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Nature Portfolio
2024-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06944-6 |
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| author | Giada Corti JangKeun Kim Francisco J. Enguita Joseph W. Guarnieri Lawrence I. Grossman Sylvain V. Costes Matias Fuentealba Ryan T. Scott Andrea Magrini Lauren M. Sanders Kanhaiya Singh Chandan K. Sen Cassandra M. Juran Amber M. Paul David Furman Jean Calleja-Agius Christopher E. Mason Diego Galeano Massimo Bottini Afshin Beheshti |
| author_facet | Giada Corti JangKeun Kim Francisco J. Enguita Joseph W. Guarnieri Lawrence I. Grossman Sylvain V. Costes Matias Fuentealba Ryan T. Scott Andrea Magrini Lauren M. Sanders Kanhaiya Singh Chandan K. Sen Cassandra M. Juran Amber M. Paul David Furman Jean Calleja-Agius Christopher E. Mason Diego Galeano Massimo Bottini Afshin Beheshti |
| author_sort | Giada Corti |
| collection | DOAJ |
| description | Abstract In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses. To address this, we identify a shared microRNA (miRNA) signature between SGA and the space environment, conserved across humans and mice. These miRNAs target genes and pathways relevant to diseases and development. Employing a machine learning approach, we identify potential FDA-approved drugs to mitigate these risks, including estrogen and progesterone receptor antagonists, vitamin D receptor antagonists, and DNA polymerase inhibitors. This study underscores potential pregnancy-related health risks for female astronauts and proposes pharmaceutical interventions to counteract the impact of space travel on female health. |
| format | Article |
| id | doaj-art-2fb443a48dab4d80aae577d65caefa4a |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-2fb443a48dab4d80aae577d65caefa4a2025-08-20T02:17:46ZengNature PortfolioCommunications Biology2399-36422024-10-017112210.1038/s42003-024-06944-6To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infantsGiada Corti0JangKeun Kim1Francisco J. Enguita2Joseph W. Guarnieri3Lawrence I. Grossman4Sylvain V. Costes5Matias Fuentealba6Ryan T. Scott7Andrea Magrini8Lauren M. Sanders9Kanhaiya Singh10Chandan K. Sen11Cassandra M. Juran12Amber M. Paul13David Furman14Jean Calleja-Agius15Christopher E. Mason16Diego Galeano17Massimo Bottini18Afshin Beheshti19Department of Experimental Medicine, University of Rome Tor VergataDepartment of Physiology, Biophysics and Systems Biology, Weill Cornell MedicineInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaCenter for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children’s Hospital of PhiladelphiaCenter for Molecular Medicine and Genetics, Wayne State University School of MedicineSpace Biosciences Division, NASA Ames Research CenterBuck Institute for Research on AgingKBR, Space Biosciences Division, NASA Ames Research CenterDepartment of Biomedicine and Prevention, University of Rome Tor VergataSpace Biosciences Division, NASA Ames Research CenterMcGowan Institute for Regenerative Medicine and Department of Surgery, University of PittsburghMcGowan Institute for Regenerative Medicine and Department of Surgery, University of PittsburghBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research CenterBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research CenterBuck Institute for Research on AgingDepartment of Anatomy, Faculty of Medicine and Surgery, University of MaltaDepartment of Physiology, Biophysics and Systems Biology, Weill Cornell MedicineFacultad de Ingeniería, Universidad Nacional de Asunción, MF9M + 958Department of Experimental Medicine, University of Rome Tor VergataMcGowan Institute for Regenerative Medicine and Department of Surgery, University of PittsburghAbstract In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses. To address this, we identify a shared microRNA (miRNA) signature between SGA and the space environment, conserved across humans and mice. These miRNAs target genes and pathways relevant to diseases and development. Employing a machine learning approach, we identify potential FDA-approved drugs to mitigate these risks, including estrogen and progesterone receptor antagonists, vitamin D receptor antagonists, and DNA polymerase inhibitors. This study underscores potential pregnancy-related health risks for female astronauts and proposes pharmaceutical interventions to counteract the impact of space travel on female health.https://doi.org/10.1038/s42003-024-06944-6 |
| spellingShingle | Giada Corti JangKeun Kim Francisco J. Enguita Joseph W. Guarnieri Lawrence I. Grossman Sylvain V. Costes Matias Fuentealba Ryan T. Scott Andrea Magrini Lauren M. Sanders Kanhaiya Singh Chandan K. Sen Cassandra M. Juran Amber M. Paul David Furman Jean Calleja-Agius Christopher E. Mason Diego Galeano Massimo Bottini Afshin Beheshti To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants Communications Biology |
| title | To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants |
| title_full | To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants |
| title_fullStr | To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants |
| title_full_unstemmed | To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants |
| title_short | To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants |
| title_sort | to boldly go where no micrornas have gone before spaceflight impact on risk for small for gestational age infants |
| url | https://doi.org/10.1038/s42003-024-06944-6 |
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