Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall
Retroperitoneal metastasis of seminoma often occurs in the higher stage through lymph nodes. Generally, seminoma expresses specific germ cell markers while being negative for carcinoma markers. We present a unique case of cytokeratin positive seminoma initially presented as retroperitoneal metastasi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/9992978 |
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| _version_ | 1849693436147400704 |
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| author | Jiaming Fan Ren Yuan David Stefanelli Gang Wang |
| author_facet | Jiaming Fan Ren Yuan David Stefanelli Gang Wang |
| author_sort | Jiaming Fan |
| collection | DOAJ |
| description | Retroperitoneal metastasis of seminoma often occurs in the higher stage through lymph nodes. Generally, seminoma expresses specific germ cell markers while being negative for carcinoma markers. We present a unique case of cytokeratin positive seminoma initially presented as retroperitoneal metastasis. The diagnosis was made based on the histological features and immunohistochemical stains. Testicular ultrasound confirmed the primary tumor in the patient’s left testicle. Pathologists should always be aware of germ cell tumors when encountering a metastasis of an unknown primary. |
| format | Article |
| id | doaj-art-2fb37482cb6148909f86227d6d4528b3 |
| institution | DOAJ |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-2fb37482cb6148909f86227d6d4528b32025-08-20T03:20:25ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/99929789992978Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic PitfallJiaming Fan0Ren Yuan1David Stefanelli2Gang Wang3Tianjin Medical University, Tianjin, ChinaDepartment of Radiology, British Columbia Cancer Vancouver Centre, Vancouver, BC, CanadaDepartment of Pathology, Royal Inland Hospital, Kamloops, BC, CanadaDepartment of Pathology, British Columbia Cancer Vancouver Centre, Vancouver, BC, CanadaRetroperitoneal metastasis of seminoma often occurs in the higher stage through lymph nodes. Generally, seminoma expresses specific germ cell markers while being negative for carcinoma markers. We present a unique case of cytokeratin positive seminoma initially presented as retroperitoneal metastasis. The diagnosis was made based on the histological features and immunohistochemical stains. Testicular ultrasound confirmed the primary tumor in the patient’s left testicle. Pathologists should always be aware of germ cell tumors when encountering a metastasis of an unknown primary.http://dx.doi.org/10.1155/2021/9992978 |
| spellingShingle | Jiaming Fan Ren Yuan David Stefanelli Gang Wang Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall Case Reports in Pathology |
| title | Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall |
| title_full | Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall |
| title_fullStr | Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall |
| title_full_unstemmed | Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall |
| title_short | Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall |
| title_sort | metastatic seminoma with positive staining of cytokeratin and moc31 a diagnostic pitfall |
| url | http://dx.doi.org/10.1155/2021/9992978 |
| work_keys_str_mv | AT jiamingfan metastaticseminomawithpositivestainingofcytokeratinandmoc31adiagnosticpitfall AT renyuan metastaticseminomawithpositivestainingofcytokeratinandmoc31adiagnosticpitfall AT davidstefanelli metastaticseminomawithpositivestainingofcytokeratinandmoc31adiagnosticpitfall AT gangwang metastaticseminomawithpositivestainingofcytokeratinandmoc31adiagnosticpitfall |