Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats

Pain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of...

Full description

Saved in:
Bibliographic Details
Main Authors: Ibrahim Abubakar, Mu'azu Abubakar Gusau, Jabir Aliyu Danyaya, Shehu Ibrahim, Zayyanu Abdullahi, Abdulhakim Zubairu, Abdulsalam Umar Sahabi
Format: Article
Language:English
Published: Plovdiv University Press 2025-01-01
Series:Journal of BioScience and Biotechnology
Subjects:
Online Access:https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/551/390
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of the ethylacetate fraction of methanol leaf extract of Hannoa klaineana in rats. The analgesic effect of the ethylacetate fraction of methanol leaves extract of Hannoa klaineana (200, 400, and 600 mg/kg b.wt) was evaluated using acetic acid-induced writhing, tail flick (immersion), and hot plate model. In the acetic acid-induced writhing test, the extract (200, 400, and 600 mg/kg) demonstrated a significant (p < 0.05) decrease in the number of writhes with maximum percentage inhibition (75.61%) at 600 mg/kg dose of the extract. In tail flick and hot plate tests, the extract (200, 400, and 600 mg/kg b.wt) exhibited a significant (p < 0.05) increase in rats’ response with a steady increase in reaction time. Findings from this study show that ethylacetate fraction of the methanol leaves extract of Hannoa klaineana possessed analgesic activity which provided justification for the local use of the plant in the treatment of pain.
ISSN:1314-6238
1314-6246