Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study
Background and Aims: Dilatation and curettage (D and C) is commonly performed as a daycare procedure under procedural sedation. We are comparing Dexmedetomidine-Ketamine (Dexket) versus Ketamine-Propofol (Ketofol) for sedation and analgesia in patients with abnormal uterine bleeding undergoing dilat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-03-01
|
| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_264_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187598274756608 |
|---|---|
| author | Ankita Kaasat Sakshi Thakore Nirdesh Thakore Mohan K. Nalliboyina Suman Kaushik |
| author_facet | Ankita Kaasat Sakshi Thakore Nirdesh Thakore Mohan K. Nalliboyina Suman Kaushik |
| author_sort | Ankita Kaasat |
| collection | DOAJ |
| description | Background and Aims:
Dilatation and curettage (D and C) is commonly performed as a daycare procedure under procedural sedation. We are comparing Dexmedetomidine-Ketamine (Dexket) versus Ketamine-Propofol (Ketofol) for sedation and analgesia in patients with abnormal uterine bleeding undergoing dilatation and curettage. Primary objective of the study was to compare time to onset of sedation and recovery. Secondary objectives included hemodynamics, time to achieve modified Aldrete score 9, number and time of additional doses of ketamine, and postoperative analgesia.
Methods:
In this randomized trial, 80 female patients, ASAI and II, 20 and 60 years, scheduled for elective D and C were analyzed. Group DK (n = 40) received inj dexmedetomidine (0.5 μg/kg) and ketamine (1 mg/kg) and group PK (n = 40) received inj ketamine (1mg/kg) and propofol (1 mg/kg). Statistical significance for continuous variables was assessed by unpaired t-test, whereas for categorical variables, Chi-square test was used. P value < 0.05 was considered as statistically significant.
Results:
Time to onset and recovery from sedation, time to achieve modified Aldrete score >9, and additional doses of ketamine were comparable in both the groups. Time to first additional ketamine dose was significantly longer in group DK. Patients in group PK had more pain postoperatively. There were no major adverse effects.
Conclusion:
Ketamine-dexmedetomidine is safe and effective alternative to ketamine-propofol for procedural sedation and analgesia in patients undergoing D and C with comparable onset and recovery times without any hemodynamic or respiratory adverse effects. |
| format | Article |
| id | doaj-art-2faa991f96b842318a77adb39ec4ca2b |
| institution | OA Journals |
| issn | 2589-8302 2589-8310 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj-art-2faa991f96b842318a77adb39ec4ca2b2025-08-20T02:16:03ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102025-03-0118225726310.4103/mjdrdypu.mjdrdypu_264_24Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind StudyAnkita KaasatSakshi ThakoreNirdesh ThakoreMohan K. NalliboyinaSuman KaushikBackground and Aims: Dilatation and curettage (D and C) is commonly performed as a daycare procedure under procedural sedation. We are comparing Dexmedetomidine-Ketamine (Dexket) versus Ketamine-Propofol (Ketofol) for sedation and analgesia in patients with abnormal uterine bleeding undergoing dilatation and curettage. Primary objective of the study was to compare time to onset of sedation and recovery. Secondary objectives included hemodynamics, time to achieve modified Aldrete score 9, number and time of additional doses of ketamine, and postoperative analgesia. Methods: In this randomized trial, 80 female patients, ASAI and II, 20 and 60 years, scheduled for elective D and C were analyzed. Group DK (n = 40) received inj dexmedetomidine (0.5 μg/kg) and ketamine (1 mg/kg) and group PK (n = 40) received inj ketamine (1mg/kg) and propofol (1 mg/kg). Statistical significance for continuous variables was assessed by unpaired t-test, whereas for categorical variables, Chi-square test was used. P value < 0.05 was considered as statistically significant. Results: Time to onset and recovery from sedation, time to achieve modified Aldrete score >9, and additional doses of ketamine were comparable in both the groups. Time to first additional ketamine dose was significantly longer in group DK. Patients in group PK had more pain postoperatively. There were no major adverse effects. Conclusion: Ketamine-dexmedetomidine is safe and effective alternative to ketamine-propofol for procedural sedation and analgesia in patients undergoing D and C with comparable onset and recovery times without any hemodynamic or respiratory adverse effects.https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_264_24dexmedetomidinedilatation and curettageketaminepropofol |
| spellingShingle | Ankita Kaasat Sakshi Thakore Nirdesh Thakore Mohan K. Nalliboyina Suman Kaushik Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study Medical Journal of Dr. D.Y. Patil Vidyapeeth dexmedetomidine dilatation and curettage ketamine propofol |
| title | Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study |
| title_full | Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study |
| title_fullStr | Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study |
| title_full_unstemmed | Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study |
| title_short | Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study |
| title_sort | comparative evaluation of dexmedetomidine ketamine versus ketamine propofol for procedural sedation during dilatation and curettage a prospective randomized double blind study |
| topic | dexmedetomidine dilatation and curettage ketamine propofol |
| url | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_264_24 |
| work_keys_str_mv | AT ankitakaasat comparativeevaluationofdexmedetomidineketamineversusketaminepropofolforproceduralsedationduringdilatationandcurettageaprospectiverandomizeddoubleblindstudy AT sakshithakore comparativeevaluationofdexmedetomidineketamineversusketaminepropofolforproceduralsedationduringdilatationandcurettageaprospectiverandomizeddoubleblindstudy AT nirdeshthakore comparativeevaluationofdexmedetomidineketamineversusketaminepropofolforproceduralsedationduringdilatationandcurettageaprospectiverandomizeddoubleblindstudy AT mohanknalliboyina comparativeevaluationofdexmedetomidineketamineversusketaminepropofolforproceduralsedationduringdilatationandcurettageaprospectiverandomizeddoubleblindstudy AT sumankaushik comparativeevaluationofdexmedetomidineketamineversusketaminepropofolforproceduralsedationduringdilatationandcurettageaprospectiverandomizeddoubleblindstudy |