IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges
Tertiary dentin results from the interplay between the host defense and dental injury or infection. Modern endodontics aiming vital pulp treatment take the tertiary dentin formation as the interim step, with the final goal of a physiological pulp-dentin like tissue regeneration. Dental pulp stem cel...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/3737346 |
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| _version_ | 1849305885290004480 |
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| author | Pengcheng He Liwei Zheng Xin Zhou |
| author_facet | Pengcheng He Liwei Zheng Xin Zhou |
| author_sort | Pengcheng He |
| collection | DOAJ |
| description | Tertiary dentin results from the interplay between the host defense and dental injury or infection. Modern endodontics aiming vital pulp treatment take the tertiary dentin formation as the interim step, with the final goal of a physiological pulp-dentin like tissue regeneration. Dental pulp stem cells have been nominated for contributing to differentiating into odontoblast-like cells who are responsible for reparative dentin formation. Understanding the original dentin formation mechanism provides us a blueprint while exploring the reparative dentin formation mechanism builds bridge to bonafide pulp-dentin tissue regeneration. Among all the regulators, growth factors have long been revealed under the spotlight. The insulin-like growth factor (IGF) family has been implicated in critical events of inducing dentin formation, which is essential for pulp treatment. The expression of IGF family members including IGF1, IGF1R, IGF2, and IGF2R has been well characterized in dental papilla cells, dental pulp stem cells, and periodontal ligament cells. Recent studies indicated IGF binding to the receptors activated pathways, including MAPK pathway, and AKT pathway, orchestrated proliferation, and differentiation, and finally, contributed to dentin formation. This review summarizes the role of IGF family in dentin formation during tooth development and tertiary dentin formation during dentin-pulp repair and sheds light on key parts of research for future treatment improvements. |
| format | Article |
| id | doaj-art-2fa9e2332d6b4a0ca4327907959e4207 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2fa9e2332d6b4a0ca4327907959e42072025-08-20T03:55:16ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/3737346IGFs in Dentin Formation and Regeneration: Progress and Remaining ChallengesPengcheng He0Liwei Zheng1Xin Zhou2State Key Laboratory of Oral DiseasesState Key Laboratory of Oral DiseasesState Key Laboratory of Oral DiseasesTertiary dentin results from the interplay between the host defense and dental injury or infection. Modern endodontics aiming vital pulp treatment take the tertiary dentin formation as the interim step, with the final goal of a physiological pulp-dentin like tissue regeneration. Dental pulp stem cells have been nominated for contributing to differentiating into odontoblast-like cells who are responsible for reparative dentin formation. Understanding the original dentin formation mechanism provides us a blueprint while exploring the reparative dentin formation mechanism builds bridge to bonafide pulp-dentin tissue regeneration. Among all the regulators, growth factors have long been revealed under the spotlight. The insulin-like growth factor (IGF) family has been implicated in critical events of inducing dentin formation, which is essential for pulp treatment. The expression of IGF family members including IGF1, IGF1R, IGF2, and IGF2R has been well characterized in dental papilla cells, dental pulp stem cells, and periodontal ligament cells. Recent studies indicated IGF binding to the receptors activated pathways, including MAPK pathway, and AKT pathway, orchestrated proliferation, and differentiation, and finally, contributed to dentin formation. This review summarizes the role of IGF family in dentin formation during tooth development and tertiary dentin formation during dentin-pulp repair and sheds light on key parts of research for future treatment improvements.http://dx.doi.org/10.1155/2022/3737346 |
| spellingShingle | Pengcheng He Liwei Zheng Xin Zhou IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges Stem Cells International |
| title | IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges |
| title_full | IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges |
| title_fullStr | IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges |
| title_full_unstemmed | IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges |
| title_short | IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges |
| title_sort | igfs in dentin formation and regeneration progress and remaining challenges |
| url | http://dx.doi.org/10.1155/2022/3737346 |
| work_keys_str_mv | AT pengchenghe igfsindentinformationandregenerationprogressandremainingchallenges AT liweizheng igfsindentinformationandregenerationprogressandremainingchallenges AT xinzhou igfsindentinformationandregenerationprogressandremainingchallenges |