Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression
Abstract Background Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. Therefore, this study aimed to clarify the effects of RSS intervention...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12868-025-00960-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849387982036926464 |
|---|---|
| author | Hiraku Watanabe Sho Kojima Naofumi Otsuru Hideaki Onishi |
| author_facet | Hiraku Watanabe Sho Kojima Naofumi Otsuru Hideaki Onishi |
| author_sort | Hiraku Watanabe |
| collection | DOAJ |
| description | Abstract Background Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. Therefore, this study aimed to clarify the effects of RSS intervention with stationary and moving pattern tactile stimulation on PPD. Results In a crossover study of 15 healthy males, RSS with a stationary pattern showed a non-significant trend toward increased PPD (corrected p = 0.088), while the moving pattern showed no effect. A strong negative correlation was found between baseline PPD and its change rate (r = − 0.837, p < 0.001), indicating that greater baseline S1 inhibition predicted a larger reduction after RSS. Conclusion RSS effects on GABAergic inhibition in S1 depend on the tactile stimulation pattern, emphasizing the importance of tactile stimulus design in modulating somatosensory cortex activity. |
| format | Article |
| id | doaj-art-2fa4cf404f2949d0a882e70d54a689a2 |
| institution | Kabale University |
| issn | 1471-2202 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj-art-2fa4cf404f2949d0a882e70d54a689a22025-08-20T03:42:26ZengBMCBMC Neuroscience1471-22022025-07-0126111010.1186/s12868-025-00960-wEffects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depressionHiraku Watanabe0Sho Kojima1Naofumi Otsuru2Hideaki Onishi3Division of Physical Therapy and Rehabilitation Medicine, University of Fukui HospitalInstitute for Human Movement and Medical Sciences, Niigata University of Health and WelfareInstitute for Human Movement and Medical Sciences, Niigata University of Health and WelfareInstitute for Human Movement and Medical Sciences, Niigata University of Health and WelfareAbstract Background Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. Therefore, this study aimed to clarify the effects of RSS intervention with stationary and moving pattern tactile stimulation on PPD. Results In a crossover study of 15 healthy males, RSS with a stationary pattern showed a non-significant trend toward increased PPD (corrected p = 0.088), while the moving pattern showed no effect. A strong negative correlation was found between baseline PPD and its change rate (r = − 0.837, p < 0.001), indicating that greater baseline S1 inhibition predicted a larger reduction after RSS. Conclusion RSS effects on GABAergic inhibition in S1 depend on the tactile stimulation pattern, emphasizing the importance of tactile stimulus design in modulating somatosensory cortex activity.https://doi.org/10.1186/s12868-025-00960-wRepetitive somatosensory stimulationElectroencephalographySomatosensory-evoked potentialsPaired-pulse depression |
| spellingShingle | Hiraku Watanabe Sho Kojima Naofumi Otsuru Hideaki Onishi Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression BMC Neuroscience Repetitive somatosensory stimulation Electroencephalography Somatosensory-evoked potentials Paired-pulse depression |
| title | Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression |
| title_full | Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression |
| title_fullStr | Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression |
| title_full_unstemmed | Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression |
| title_short | Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression |
| title_sort | effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired pulse depression |
| topic | Repetitive somatosensory stimulation Electroencephalography Somatosensory-evoked potentials Paired-pulse depression |
| url | https://doi.org/10.1186/s12868-025-00960-w |
| work_keys_str_mv | AT hirakuwatanabe effectsofrepetitivemechanicaltactilestimulationinterventionswithstationaryandmovingpatternsonpairedpulsedepression AT shokojima effectsofrepetitivemechanicaltactilestimulationinterventionswithstationaryandmovingpatternsonpairedpulsedepression AT naofumiotsuru effectsofrepetitivemechanicaltactilestimulationinterventionswithstationaryandmovingpatternsonpairedpulsedepression AT hideakionishi effectsofrepetitivemechanicaltactilestimulationinterventionswithstationaryandmovingpatternsonpairedpulsedepression |