Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer
We aimed to assess the relationship between bone scintigraphy findings and prostate-specific antigen (PSA) and Gleason score in a group of treatment naïve West Africans with prostate cancer. The age, PSA, and Gleason scores of 363 patients with prostate cancer were collected. Patients were risk stra...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | World Journal of Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.wjnm.org/article.asp?issn=1450-1147;year=2019;volume=18;issue=2;spage=143;epage=148;aulast=Amoako |
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| author | Yaw Ampem Amoako Emmanuel Nii Boye Hammond Awo Assasie-Gyimah Dennis Odai Laryea Alfred Ankrah George Amoah |
| author_facet | Yaw Ampem Amoako Emmanuel Nii Boye Hammond Awo Assasie-Gyimah Dennis Odai Laryea Alfred Ankrah George Amoah |
| author_sort | Yaw Ampem Amoako |
| collection | DOAJ |
| description | We aimed to assess the relationship between bone scintigraphy findings and prostate-specific antigen (PSA) and Gleason score in a group of treatment naïve West Africans with prostate cancer. The age, PSA, and Gleason scores of 363 patients with prostate cancer were collected. Patients were risk stratified using the D'Amico criteria. Logistic regression was performed to assess the relationship between bone scan results and PSA and Gleason score. Receiver operating characteristics (ROC) analysis was used to determine the diagnostic reliability of the bone scan findings. Ninety of the 96 patients with metastases had high risk, and only 6 had low-to-intermediate risk disease (P = 0.0001). PSA (odds ratio [OR] 2.4 [95% confidence interval [CI] 1.5–3.8], P = 0.001) and GS (OR 2.2 [95% CI 1.5–3.1], P = 0.001) were independently predictive of the presence of metastases. ROC analysis revealed that PSA predicted the presence of metastases with an area under the curve of 0.72, and using a cut-off value of ≥20 predicted metastases with a sensitivity of 86.5% and specificity of 41.2%. A Gleason score of ≥7 had an 89.6% sensitivity and 34.8% specificity for bone metastases. Using a Gleason cutoff of ≥8, the sensitivity and specificity for predicting bone metastases were 54.2% and 71.5%, respectively. The area under the Gleason score ROC curve was 0.68. PSA and Gleason score are independent predictors of the presence of bone metastases in West Africans with prostate cancer. |
| format | Article |
| id | doaj-art-2fa0e5a9ff1e44a18dec53a6761b8283 |
| institution | OA Journals |
| issn | 1450-1147 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-2fa0e5a9ff1e44a18dec53a6761b82832025-08-20T02:01:47ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11472019-01-0118214314810.4103/wjnm.WJNM_38_18Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancerYaw Ampem AmoakoEmmanuel Nii Boye HammondAwo Assasie-GyimahDennis Odai LaryeaAlfred AnkrahGeorge AmoahWe aimed to assess the relationship between bone scintigraphy findings and prostate-specific antigen (PSA) and Gleason score in a group of treatment naïve West Africans with prostate cancer. The age, PSA, and Gleason scores of 363 patients with prostate cancer were collected. Patients were risk stratified using the D'Amico criteria. Logistic regression was performed to assess the relationship between bone scan results and PSA and Gleason score. Receiver operating characteristics (ROC) analysis was used to determine the diagnostic reliability of the bone scan findings. Ninety of the 96 patients with metastases had high risk, and only 6 had low-to-intermediate risk disease (P = 0.0001). PSA (odds ratio [OR] 2.4 [95% confidence interval [CI] 1.5–3.8], P = 0.001) and GS (OR 2.2 [95% CI 1.5–3.1], P = 0.001) were independently predictive of the presence of metastases. ROC analysis revealed that PSA predicted the presence of metastases with an area under the curve of 0.72, and using a cut-off value of ≥20 predicted metastases with a sensitivity of 86.5% and specificity of 41.2%. A Gleason score of ≥7 had an 89.6% sensitivity and 34.8% specificity for bone metastases. Using a Gleason cutoff of ≥8, the sensitivity and specificity for predicting bone metastases were 54.2% and 71.5%, respectively. The area under the Gleason score ROC curve was 0.68. PSA and Gleason score are independent predictors of the presence of bone metastases in West Africans with prostate cancer.http://www.wjnm.org/article.asp?issn=1450-1147;year=2019;volume=18;issue=2;spage=143;epage=148;aulast=AmoakoBone scintigraphyGhanaGleason scoreprostate cancerprostate-specific antigen |
| spellingShingle | Yaw Ampem Amoako Emmanuel Nii Boye Hammond Awo Assasie-Gyimah Dennis Odai Laryea Alfred Ankrah George Amoah Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer World Journal of Nuclear Medicine Bone scintigraphy Ghana Gleason score prostate cancer prostate-specific antigen |
| title | Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer |
| title_full | Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer |
| title_fullStr | Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer |
| title_full_unstemmed | Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer |
| title_short | Prostate-specific antigen and risk of bone metastases in west Africans with prostate cancer |
| title_sort | prostate specific antigen and risk of bone metastases in west africans with prostate cancer |
| topic | Bone scintigraphy Ghana Gleason score prostate cancer prostate-specific antigen |
| url | http://www.wjnm.org/article.asp?issn=1450-1147;year=2019;volume=18;issue=2;spage=143;epage=148;aulast=Amoako |
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