Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review
<b>Background:</b> Psoriasis is a prevalent and persistent inflammatory disorder with systemic manifestations. Emerging evidence implicates the gut microbiota in regulating inflammatory responses, metabolic pathways, and immune homeostasis. This review synthesizes current evidence on gut...
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MDPI AG
2025-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/4/358 |
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| author | Yingjun Gao Yanfeng Lou Yun Hui Huan Chen Hong Sang Fang Liu |
| author_facet | Yingjun Gao Yanfeng Lou Yun Hui Huan Chen Hong Sang Fang Liu |
| author_sort | Yingjun Gao |
| collection | DOAJ |
| description | <b>Background:</b> Psoriasis is a prevalent and persistent inflammatory disorder with systemic manifestations. Emerging evidence implicates the gut microbiota in regulating inflammatory responses, metabolic pathways, and immune homeostasis. This review synthesizes current evidence on gut microbiota dysbiosis in psoriasis and evaluates the therapeutic potential of probiotics and fecal microbiota transplantation (FMT) in disease management. <b>Method:</b> Following PRISMA guidelines, we systematically reviewed studies investigating gut microbiome profiles in psoriasis through the MEDLINE, EMBASE, and Web of Science databases (January 2015–December 2024). Included studies utilized 16S rRNA gene sequencing or metagenomic analyses for microbial characterization. <b>Results:</b> Comparative analyses revealed distinct gut microbiota patterns in psoriasis patients compared with healthy controls, although specific microbial signatures exhibited inconsistencies across studies. Notably, interventions modulating gut microbiota composition—particularly probiotic supplementation—demonstrated measurable improvements in psoriasis severity scores and inflammatory markers. <b>Conclusions:</b> Gut microbiome modulation represents a promising therapeutic strategy for psoriasis; however, current evidence highlights the need for standardized microbial analysis methodologies and larger longitudinal studies to establish causality. Future research should prioritize the functional characterization of microbiota–host interactions to optimize therapeutic applications. |
| format | Article |
| id | doaj-art-2f9fdf5889e1471a9cd4102526f7bbae |
| institution | DOAJ |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-2f9fdf5889e1471a9cd4102526f7bbae2025-08-20T03:13:50ZengMDPI AGPathogens2076-08172025-04-0114435810.3390/pathogens14040358Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic ReviewYingjun Gao0Yanfeng Lou1Yun Hui2Huan Chen3Hong Sang4Fang Liu5Department of Dermatology, Jinling Hospital, Nanjing Medical University, Nanjing 210002, ChinaDepartment of Stomatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, ChinaDepartment of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, ChinaDepartment of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, ChinaDepartment of Dermatology, Jinling Hospital, Nanjing Medical University, Nanjing 210002, ChinaDepartment of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China<b>Background:</b> Psoriasis is a prevalent and persistent inflammatory disorder with systemic manifestations. Emerging evidence implicates the gut microbiota in regulating inflammatory responses, metabolic pathways, and immune homeostasis. This review synthesizes current evidence on gut microbiota dysbiosis in psoriasis and evaluates the therapeutic potential of probiotics and fecal microbiota transplantation (FMT) in disease management. <b>Method:</b> Following PRISMA guidelines, we systematically reviewed studies investigating gut microbiome profiles in psoriasis through the MEDLINE, EMBASE, and Web of Science databases (January 2015–December 2024). Included studies utilized 16S rRNA gene sequencing or metagenomic analyses for microbial characterization. <b>Results:</b> Comparative analyses revealed distinct gut microbiota patterns in psoriasis patients compared with healthy controls, although specific microbial signatures exhibited inconsistencies across studies. Notably, interventions modulating gut microbiota composition—particularly probiotic supplementation—demonstrated measurable improvements in psoriasis severity scores and inflammatory markers. <b>Conclusions:</b> Gut microbiome modulation represents a promising therapeutic strategy for psoriasis; however, current evidence highlights the need for standardized microbial analysis methodologies and larger longitudinal studies to establish causality. Future research should prioritize the functional characterization of microbiota–host interactions to optimize therapeutic applications.https://www.mdpi.com/2076-0817/14/4/358psoriasisgut microbiomeprobioticsfecal microbiota transplantation |
| spellingShingle | Yingjun Gao Yanfeng Lou Yun Hui Huan Chen Hong Sang Fang Liu Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review Pathogens psoriasis gut microbiome probiotics fecal microbiota transplantation |
| title | Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review |
| title_full | Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review |
| title_fullStr | Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review |
| title_full_unstemmed | Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review |
| title_short | Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review |
| title_sort | characterization of the gut microbiota in patients with psoriasis a systematic review |
| topic | psoriasis gut microbiome probiotics fecal microbiota transplantation |
| url | https://www.mdpi.com/2076-0817/14/4/358 |
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