Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration

Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration

Abstract Objectives This study focuses on the preventive and therapeutic effects of Dihydroartemisinin (DHA) on Alzheimer’s disease (AD) model mice and the effects of DHA and donepezil on amyloid β-protein deposition and autophagy in nerve cells. Methods Six autophagy related targets were selected f...

Full description

Saved in:

Bibliographic Details
Main Authors:	Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	European Journal of Medical Research
Subjects:	Alzheimer’s disease Age-related macular degeneration Dihydroartemisinin Amyloid β-protein deposition
Online Access:	https://doi.org/10.1186/s40001-025-02315-x
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration
by: Hongfan Yang, et al.
Published: (2025-02-01)

CD22 modulation alleviates amyloid β-induced neuroinflammation
by: Yu Dong Mai, et al.
Published: (2025-02-01)

Modeling pegcetacoplan treatment effect for atrophic age-related macular degeneration with AI-based progression prediction
by: Irmela Mantel, et al.
Published: (2025-02-01)

Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease
by: Arif Malik, et al.
Published: (2025-02-01)

Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration
by: Hamid Riazi-Esfahani, et al.
Published: (2025-02-01)

Abca4, mutated in Stargardt disease, is required for structural integrity of cone outer segments
by: John J. Willoughby, et al.
Published: (2025-01-01)

Predicting amyloid proteins using attention-based long short-term memory
by: Zhuowen Li
Published: (2025-02-01)

Management of traumatic macular hole and retinal detachment using amniotic membrane transplantation: A case report
by: Marcus H. Yamamoto, et al.
Published: (2025-03-01)

Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models
by: Lisa Blackmer-Raynolds, et al.
Published: (2025-02-01)

Some Representations of the Modified Degenerate Gamma Matrix Function
by: İnci Ege, et al.
Published: (2024-10-01)

The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration
by: Eliasz Engelhardt, et al.
Published: (2025-02-01)

Application of deep learning algorithm for judicious use of anti-VEGF in diabetic macular edema
by: Anwesa Mondal, et al.
Published: (2025-02-01)

Modified autologous neurosensory retinal transplantation and bevacizumab injection in primary extra-large chronic macular holes
by: Hossein Ashraf, et al.
Published: (2025-06-01)

The Science of Memory Loss: Insights into Alzheimer’s Disease
by: Agnieszka Starzyk, et al.
Published: (2025-02-01)

Fighting Alzheimer’s with Movement: The Role of Physical Activity in Disease Management
by: Agnieszka Kosińska, et al.
Published: (2025-02-01)

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease
by: Tian Meng, et al.
Published: (2025-02-01)

Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease
by: Hua-xiong Zhang, et al.
Published: (2025-02-01)

Prognostics optical coherence tomography biomarker in macular oedema secondary to retinal vein occlusion
by: Andrea R. Silitonga, et al.
Published: (2025-01-01)

The effect of mild-stage Alzheimer’s disease on the acoustic parameters of voice
by: Emel Arslan-Sarımehmetoğlu, et al.
Published: (2025-02-01)

Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia
by: Shuwen Zheng, et al.
Published: (2025-02-01)

Application of Low Intensity Ultrasound in the Treatment of Alzheimer’s Disease
by: Hong Fei, Xu Fei
Published: (2025-03-01)

Evaluation of machine learning models for the prediction of Alzheimer's: In search of the best performance
by: Michael Cabanillas-Carbonell, et al.
Published: (2025-03-01)

Difference of Disk Degeneration and Segmental Range of Motion due to Lumbar Disk Level among Age and Gender: 639 Asymptomatic Volunteer Data
by: Tomohiro Yamada, et al.
Published: (2025-01-01)

CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy
by: Yongbo Zhang, et al.
Published: (2025-02-01)

Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring
by: Fengxu Wang, et al.
Published: (2025-01-01)

Comparison of optical coherence tomography vs. fluorescein angiography-based macular neovascularization classifications in age-related macular degeneration
by: Gábor G. Deák, et al.
Published: (2025-02-01)

Influence of immune cells and inflammatory factors on Alzheimer’s disease axis: evidence from mediation Mendelian randomization study
by: Linzhu, et al.
Published: (2025-02-01)

Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease
by: Zhou H, et al.
Published: (2025-02-01)

The Impact of Care Upon Alzheimer Patient’s Family Caregiver in Sulaimani City
by: Farida Abdulqadir Tahir
Published: (2019-06-01)

Transforming Alzheimer’s Disease Diagnosis: Implementing Vision Transformer (ViT) for MRI Images Classification
by: Dian Kurniasari, et al.
Published: (2025-01-01)

A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors
by: Joan Nieves, et al.
Published: (2025-02-01)

Knowledge and attitudes towards Alzheimer’s disease and related dementias among Nigerian medical and nursing students: a comparative study
by: Tobi Olajide, et al.
Published: (2025-02-01)

Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle and Older Age for an Average of 6.9 Years
by: Tsutomu Akazawa, et al.
Published: (2025-01-01)

Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy
by: Zexia Dou, et al.
Published: (2025-02-01)

Danggui-Shaoyao-San Can Ameliorate Alzheimer’s Disease by Inhibiting Hippocampal Neuron Apoptosis: Findings from Serum Pharmacology
by: Zhang KX, et al.
Published: (2025-02-01)

Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy
by: Danielle Sidsworth, et al.
Published: (2025-02-01)

Functional and effective EEG connectivity patterns in Alzheimer’s disease and mild cognitive impairment: a systematic review
by: Elizabeth R. Paitel, et al.
Published: (2025-02-01)

Amorphous Extracellular Eosinophilic Material – The Diagnostic Challenge in Histopathology
by: P. Sivakumar, et al.
Published: (2025-01-01)

Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease
by: Waimao Gao, et al.
Published: (2025-02-01)

Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease
by: Amtul Rahman, et al.
Published: (2024-12-01)