Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases
Microglial cells are responsible for immune surveillance within the CNS. They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response. This is followed by release of anti-inflammatory mediators and resolution of the inflammatory response. Altera...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5048616 |
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| author | Lila Carniglia Delia Ramírez Daniela Durand Julieta Saba Juan Turati Carla Caruso Teresa N. Scimonelli Mercedes Lasaga |
| author_facet | Lila Carniglia Delia Ramírez Daniela Durand Julieta Saba Juan Turati Carla Caruso Teresa N. Scimonelli Mercedes Lasaga |
| author_sort | Lila Carniglia |
| collection | DOAJ |
| description | Microglial cells are responsible for immune surveillance within the CNS. They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response. This is followed by release of anti-inflammatory mediators and resolution of the inflammatory response. Alterations to this delicate process may lead to tissue damage, neuroinflammation, and neurodegeneration. Chronic pain, such as inflammatory or neuropathic pain, is accompanied by neuroimmune activation, and the role of glial cells in the initiation and maintenance of chronic pain has been the subject of increasing research over the last two decades. Neuropeptides are small amino acidic molecules with the ability to regulate neuronal activity and thereby affect various functions such as thermoregulation, reproductive behavior, food and water intake, and circadian rhythms. Neuropeptides can also affect inflammatory responses and pain sensitivity by modulating the activity of glial cells. The last decade has witnessed growing interest in the study of microglial activation and its modulation by neuropeptides in the hope of developing new therapeutics for treating neurodegenerative diseases and chronic pain. This review summarizes the current literature on the way in which several neuropeptides modulate microglial activity and response to tissue damage and how this modulation may affect pain sensitivity. |
| format | Article |
| id | doaj-art-2f9fa278694c457a918be1b90d40fc3a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2f9fa278694c457a918be1b90d40fc3a2025-08-20T03:55:16ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/50486165048616Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative DiseasesLila Carniglia0Delia Ramírez1Daniela Durand2Julieta Saba3Juan Turati4Carla Caruso5Teresa N. Scimonelli6Mercedes Lasaga7INBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaINBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaINBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaINBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaINBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaINBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaIFEC-CONICET, Depto. Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaINBIOMED (Instituto de Investigaciones Biomédicas), UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad Autónoma de Buenos Aires, ArgentinaMicroglial cells are responsible for immune surveillance within the CNS. They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response. This is followed by release of anti-inflammatory mediators and resolution of the inflammatory response. Alterations to this delicate process may lead to tissue damage, neuroinflammation, and neurodegeneration. Chronic pain, such as inflammatory or neuropathic pain, is accompanied by neuroimmune activation, and the role of glial cells in the initiation and maintenance of chronic pain has been the subject of increasing research over the last two decades. Neuropeptides are small amino acidic molecules with the ability to regulate neuronal activity and thereby affect various functions such as thermoregulation, reproductive behavior, food and water intake, and circadian rhythms. Neuropeptides can also affect inflammatory responses and pain sensitivity by modulating the activity of glial cells. The last decade has witnessed growing interest in the study of microglial activation and its modulation by neuropeptides in the hope of developing new therapeutics for treating neurodegenerative diseases and chronic pain. This review summarizes the current literature on the way in which several neuropeptides modulate microglial activity and response to tissue damage and how this modulation may affect pain sensitivity.http://dx.doi.org/10.1155/2017/5048616 |
| spellingShingle | Lila Carniglia Delia Ramírez Daniela Durand Julieta Saba Juan Turati Carla Caruso Teresa N. Scimonelli Mercedes Lasaga Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases Mediators of Inflammation |
| title | Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases |
| title_full | Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases |
| title_fullStr | Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases |
| title_full_unstemmed | Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases |
| title_short | Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases |
| title_sort | neuropeptides and microglial activation in inflammation pain and neurodegenerative diseases |
| url | http://dx.doi.org/10.1155/2017/5048616 |
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