Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents
The association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. We investigated sarcopenia’s impact on NAFLD severity and its relationship with cardiometabolic risk in adolescents. We conducted a retrospective study on 122 patients aged 13–18 years and diagnosed w...
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2024-11-01
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| author | Yoowon Kwon Jin A Chung You Jin Choi Yoo Min Lee So Yoon Choi In Hyuk Yoo Tae Hyeong Kim Su Jin Jeong |
| author_facet | Yoowon Kwon Jin A Chung You Jin Choi Yoo Min Lee So Yoon Choi In Hyuk Yoo Tae Hyeong Kim Su Jin Jeong |
| author_sort | Yoowon Kwon |
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| description | The association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. We investigated sarcopenia’s impact on NAFLD severity and its relationship with cardiometabolic risk in adolescents. We conducted a retrospective study on 122 patients aged 13–18 years and diagnosed with both NAFLD and sarcopenia by laboratory tests, abdominal ultrasound (US), and multifrequency bioelectrical impedance analysis. Sarcopenia was stratified into tertiles based on the skeletal muscle-to-fat ratio (MFR), NAFLD severity was established by the US, and cardiometabolic risk was assessed by the triglyceride–glucose (TyG) index and the atherogenic index of plasma (AIP). Compared with the other patients, those in the lower MFR tertiles exhibited a greater severity of NAFLD (<i>p</i> < 0.001) and significantly higher TyG index and AIP. The independent effect of MFR was observed to have a negative correlation with the severity of NAFLD (<i>p</i> < 0.001). Based on the aforementioned results, the degree of sarcopenia can be considered as one of the risk factors of severe NAFLD and might be an indicator of cardiometabolic risk in adolescents. Weight training to reach the amount of muscle mass could be included in the treatment strategies to improve or prevent NAFLD in adolescents with sarcopenia. |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-2f9f6dae15944a2a8e0d4a7b72adb3a62025-08-20T02:05:03ZengMDPI AGLife2075-17292024-11-011411145710.3390/life14111457Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in AdolescentsYoowon Kwon0Jin A Chung1You Jin Choi2Yoo Min Lee3So Yoon Choi4In Hyuk Yoo5Tae Hyeong Kim6Su Jin Jeong7Department of Pediatrics, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong 30099, Republic of KoreaDepartment of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of KoreaDepartment of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Ilsan 10380, Republic of KoreaDepartment of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Republic of KoreaDepartment of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan 49267, Republic of KoreaDepartment of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul 05278, Republic of KoreaDepartment of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of KoreaThe association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. We investigated sarcopenia’s impact on NAFLD severity and its relationship with cardiometabolic risk in adolescents. We conducted a retrospective study on 122 patients aged 13–18 years and diagnosed with both NAFLD and sarcopenia by laboratory tests, abdominal ultrasound (US), and multifrequency bioelectrical impedance analysis. Sarcopenia was stratified into tertiles based on the skeletal muscle-to-fat ratio (MFR), NAFLD severity was established by the US, and cardiometabolic risk was assessed by the triglyceride–glucose (TyG) index and the atherogenic index of plasma (AIP). Compared with the other patients, those in the lower MFR tertiles exhibited a greater severity of NAFLD (<i>p</i> < 0.001) and significantly higher TyG index and AIP. The independent effect of MFR was observed to have a negative correlation with the severity of NAFLD (<i>p</i> < 0.001). Based on the aforementioned results, the degree of sarcopenia can be considered as one of the risk factors of severe NAFLD and might be an indicator of cardiometabolic risk in adolescents. Weight training to reach the amount of muscle mass could be included in the treatment strategies to improve or prevent NAFLD in adolescents with sarcopenia.https://www.mdpi.com/2075-1729/14/11/1457nonalcoholic fatty liver diseaseskeletal muscle masssarcopeniatriglyceride and glucose indexatherogenic index of plasma |
| spellingShingle | Yoowon Kwon Jin A Chung You Jin Choi Yoo Min Lee So Yoon Choi In Hyuk Yoo Tae Hyeong Kim Su Jin Jeong Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents Life nonalcoholic fatty liver disease skeletal muscle mass sarcopenia triglyceride and glucose index atherogenic index of plasma |
| title | Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents |
| title_full | Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents |
| title_fullStr | Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents |
| title_full_unstemmed | Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents |
| title_short | Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents |
| title_sort | relationship of the degree of sarcopenia with the severity of nonalcoholic fatty liver disease and cardiometabolic risk in adolescents |
| topic | nonalcoholic fatty liver disease skeletal muscle mass sarcopenia triglyceride and glucose index atherogenic index of plasma |
| url | https://www.mdpi.com/2075-1729/14/11/1457 |
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