GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients

GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients

IntroductionCRLF2 abnormalities are prevalent in Hispanics from the U.S. and Mexican children with pre-B acute lymphoblastic leukemia (ALL). This trait is associated with unfavorable prognosis. Furthermore, SNPs rs3824662 and rs3781093 in GATA3 have been associated with an increased risk of pre-B AL...

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Main Authors: Adriana Reyes-León, Eduardo Castro-Vargas, Ma. del Rocío Juárez-Velázquez, Daniel Martínez Anaya, Consuelo Salas-Labadía, Dafné Moreno-Lorenzana, César Alejandro Galván-Díaz, Norma López-Santiago, Eduardo García-Padilla, Alda Daniela García-Guzmán, Isabel Medina-Vera, Patricia Pérez-Vera
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
pre-B acute lymphoblastic leukemia
Mexicans
children
overweight
obesity
CRLF2 overexpression
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1533756/full
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