GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients
IntroductionCRLF2 abnormalities are prevalent in Hispanics from the U.S. and Mexican children with pre-B acute lymphoblastic leukemia (ALL). This trait is associated with unfavorable prognosis. Furthermore, SNPs rs3824662 and rs3781093 in GATA3 have been associated with an increased risk of pre-B AL...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1533756/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849313420158959616 |
|---|---|
| author | Adriana Reyes-León Eduardo Castro-Vargas Eduardo Castro-Vargas Ma. del Rocío Juárez-Velázquez Daniel Martínez Anaya Consuelo Salas-Labadía Dafné Moreno-Lorenzana César Alejandro Galván-Díaz Norma López-Santiago Eduardo García-Padilla Eduardo García-Padilla Alda Daniela García-Guzmán Isabel Medina-Vera Patricia Pérez-Vera |
| author_facet | Adriana Reyes-León Eduardo Castro-Vargas Eduardo Castro-Vargas Ma. del Rocío Juárez-Velázquez Daniel Martínez Anaya Consuelo Salas-Labadía Dafné Moreno-Lorenzana César Alejandro Galván-Díaz Norma López-Santiago Eduardo García-Padilla Eduardo García-Padilla Alda Daniela García-Guzmán Isabel Medina-Vera Patricia Pérez-Vera |
| author_sort | Adriana Reyes-León |
| collection | DOAJ |
| description | IntroductionCRLF2 abnormalities are prevalent in Hispanics from the U.S. and Mexican children with pre-B acute lymphoblastic leukemia (ALL). This trait is associated with unfavorable prognosis. Furthermore, SNPs rs3824662 and rs3781093 in GATA3 have been associated with an increased risk of pre-B ALL. In particular, rs3824662 is associated with CRLF2-ALL, with a higher prevalence in Hispanic patients. Additionally, rs3824662 is associated with adipogenesis, since Hispanic patients have a high prevalence of obesity and overweight, it has been suggested that obesity predisposes to CRLF2-ALL.MethodsIn this study, we evaluated rs3824662 and rs3781093 as predisposition markers for pre-B ALL in Mexican children using Taqman probes.ResultsBoth risk alleles were found to be associated with susceptibility to pre-B ALL, predisposition to CRLF2-ALL, overweight status, and overall survival. The risk alleles of both SNPs in Mexican patients were among the most frequent compared with other non-Amerindian populations. SNP rs3824662 and rs3781093 were informative for our patients. Analysis of nutritional status indicated that GATA3 alleles may impact overweight status.DiscussionFurther studies on the relationship between nutritional status and GATA3, as well as analysis of other Amerindian ALL populations, are recommended. |
| format | Article |
| id | doaj-art-2f9c36c6740f4a6983cd2acc3df2c531 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-2f9c36c6740f4a6983cd2acc3df2c5312025-08-20T03:52:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15337561533756GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patientsAdriana Reyes-León0Eduardo Castro-Vargas1Eduardo Castro-Vargas2Ma. del Rocío Juárez-Velázquez3Daniel Martínez Anaya4Consuelo Salas-Labadía5Dafné Moreno-Lorenzana6César Alejandro Galván-Díaz7Norma López-Santiago8Eduardo García-Padilla9Eduardo García-Padilla10Alda Daniela García-Guzmán11Isabel Medina-Vera12Patricia Pérez-Vera13Laboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoLaboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoBecario de la Dirección General de Calidad y Educación en Salud, Secretaría de Salud, México, MexicoLaboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoLaboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoLaboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoCONAHCYT-Instituto Nacional de Pediatría, Ciudad de México, MexicoServicio de Oncología, Instituto Nacional de Pediatría, Ciudad de México, MexicoServicio de Hematología, Instituto Nacional de Pediatría, Ciudad de México, MexicoLaboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoBecario de la Dirección General de Calidad y Educación en Salud, Secretaría de Salud, México, MexicoServicio de Oncología, Instituto Nacional de Pediatría, Ciudad de México, MexicoDepartamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Ciudad de México, MexicoLaboratorio de Genética y Cáncer, Instituto Nacional de Pediatría, Ciudad de México, MexicoIntroductionCRLF2 abnormalities are prevalent in Hispanics from the U.S. and Mexican children with pre-B acute lymphoblastic leukemia (ALL). This trait is associated with unfavorable prognosis. Furthermore, SNPs rs3824662 and rs3781093 in GATA3 have been associated with an increased risk of pre-B ALL. In particular, rs3824662 is associated with CRLF2-ALL, with a higher prevalence in Hispanic patients. Additionally, rs3824662 is associated with adipogenesis, since Hispanic patients have a high prevalence of obesity and overweight, it has been suggested that obesity predisposes to CRLF2-ALL.MethodsIn this study, we evaluated rs3824662 and rs3781093 as predisposition markers for pre-B ALL in Mexican children using Taqman probes.ResultsBoth risk alleles were found to be associated with susceptibility to pre-B ALL, predisposition to CRLF2-ALL, overweight status, and overall survival. The risk alleles of both SNPs in Mexican patients were among the most frequent compared with other non-Amerindian populations. SNP rs3824662 and rs3781093 were informative for our patients. Analysis of nutritional status indicated that GATA3 alleles may impact overweight status.DiscussionFurther studies on the relationship between nutritional status and GATA3, as well as analysis of other Amerindian ALL populations, are recommended.https://www.frontiersin.org/articles/10.3389/fonc.2025.1533756/fullpre-B acute lymphoblastic leukemiaMexicanschildrenoverweightobesityCRLF2 overexpression |
| spellingShingle | Adriana Reyes-León Eduardo Castro-Vargas Eduardo Castro-Vargas Ma. del Rocío Juárez-Velázquez Daniel Martínez Anaya Consuelo Salas-Labadía Dafné Moreno-Lorenzana César Alejandro Galván-Díaz Norma López-Santiago Eduardo García-Padilla Eduardo García-Padilla Alda Daniela García-Guzmán Isabel Medina-Vera Patricia Pérez-Vera GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients Frontiers in Oncology pre-B acute lymphoblastic leukemia Mexicans children overweight obesity CRLF2 overexpression |
| title | GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients |
| title_full | GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients |
| title_fullStr | GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients |
| title_full_unstemmed | GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients |
| title_short | GATA3 germline variants in childhood pre-B acute lymphoblastic leukemia: association with CRLF2 overexpression and overweight in Mexican patients |
| title_sort | gata3 germline variants in childhood pre b acute lymphoblastic leukemia association with crlf2 overexpression and overweight in mexican patients |
| topic | pre-B acute lymphoblastic leukemia Mexicans children overweight obesity CRLF2 overexpression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1533756/full |
| work_keys_str_mv | AT adrianareyesleon gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT eduardocastrovargas gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT eduardocastrovargas gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT madelrociojuarezvelazquez gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT danielmartinezanaya gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT consuelosalaslabadia gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT dafnemorenolorenzana gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT cesaralejandrogalvandiaz gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT normalopezsantiago gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT eduardogarciapadilla gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT eduardogarciapadilla gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT aldadanielagarciaguzman gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT isabelmedinavera gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients AT patriciaperezvera gata3germlinevariantsinchildhoodprebacutelymphoblasticleukemiaassociationwithcrlf2overexpressionandoverweightinmexicanpatients |