Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production
IntroductionDespite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since the impact of COVID-19 vaccines on the endothelium remains uncertain, our objective was to assess endothelial activation status before and 90 days after the third dos...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1471401/full |
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| author | Beatriz Castro-Robles Francisco J. Cimas Francisco J. Cimas Lourdes Arias-Salazar Jesús Ontañón Julia Lozano Susana López-López Fernando Andrés-Pretel María Ángeles Requena-Calleja Antonio Mas Antonio Mas Antonio Mas Gemma Serrano-Heras Tomás Segura Tomás Segura Javier Solera |
| author_facet | Beatriz Castro-Robles Francisco J. Cimas Francisco J. Cimas Lourdes Arias-Salazar Jesús Ontañón Julia Lozano Susana López-López Fernando Andrés-Pretel María Ángeles Requena-Calleja Antonio Mas Antonio Mas Antonio Mas Gemma Serrano-Heras Tomás Segura Tomás Segura Javier Solera |
| author_sort | Beatriz Castro-Robles |
| collection | DOAJ |
| description | IntroductionDespite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since the impact of COVID-19 vaccines on the endothelium remains uncertain, our objective was to assess endothelial activation status before and 90 days after the third dose of the BNT162b2 mRNA COVID-19 vaccine.MethodsA prospective longitudinal study was conducted at University General Hospital of Albacete, involving 38 healthy health-care workers. Serum levels of endothelial markers (endocan and sVCAM-1) and spike S1-specific IgG antibodies were determined before and at 7, 15, 24 and 90days following vaccination. To analyze each participant´s individual response, we calculated relative increases/decreases (delta values) in endothelial markers and antibodies concentrations compared to their pre-vaccination levels.ResultsWe identified two significantly distinct profiles of endothelial markers response, characterized by either increased or decreased serum levels of endocan and sVCAM. Incremental and decremental response groups did not differ in terms of age, sex, cardiovascular risk factors, previous SARS-CoV-2 infection and influenza vaccine co-administration. However, these responses were significantly associated with the relative spike-specific antibody production. Specifically, the greatest relative increase in antibodies was found in the decremental responders. Additionally, the higher delta antibody production was observed in non-previously infected individualsConclusionAdministration of the BNT162b2 booster vaccine triggered a non-homogenous response of endothelial function markers among the study participants. Our findings improve the understanding of individual responses to the mRNA COVID-19 booster vaccine, which could be useful in assessing the need for booster doses, particularly in population at risk of vascular complications. |
| format | Article |
| id | doaj-art-2f9b4bb6bc9746e49babc47320e73ab2 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-2f9b4bb6bc9746e49babc47320e73ab22025-01-06T06:59:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14714011471401Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody productionBeatriz Castro-Robles0Francisco J. Cimas1Francisco J. Cimas2Lourdes Arias-Salazar3Jesús Ontañón4Julia Lozano5Susana López-López6Fernando Andrés-Pretel7María Ángeles Requena-Calleja8Antonio Mas9Antonio Mas10Antonio Mas11Gemma Serrano-Heras12Tomás Segura13Tomás Segura14Javier Solera15Research Unit, General University Hospital of Albacete, Health Service of Castilla-La Mancha (SESCAM), Albacete, SpainMolecular Oncology Laboratory, Molecular Medicine Unit, Associated Unit of Biomedicine, University of Castilla-La Mancha-Spanish National Research Council (UCLM-CSIC), Albacete, SpainMecenazgo COVID-19, Faculty of Medicine, University of Castilla-La Mancha, Albacete, SpainResearch Unit, General University Hospital of Albacete, Health Service of Castilla-La Mancha (SESCAM), Albacete, SpainImmunology Unit, Clinical Analysis Department, General University Hospital of Albacete, Albacete, SpainMicrobiology Department, General University Hospital of Albacete, Albacete, SpainResearch Unit, General University Hospital of Albacete, Health Service of Castilla-La Mancha (SESCAM), Albacete, SpainResearch Unit, General University Hospital of Albacete, Department of Statistics, Foundation of the National Paraplegics Hospital of Toledo, Albacete, SpainInternal Medicine Department, General University Hospital of Albacete, Albacete, SpainBiomedicine Institute of UCLM (IB-UCLM), Faculty of Medicine, University of Castilla-La Mancha, Albacete, SpainFaculty of Pharmacy, University of Castilla-La Mancha, Albacete, Spain0Associated Unit of Biomedicine UCLM-CSIC, University of Castilla-La Mancha, Ciudad Real, SpainResearch Unit, General University Hospital of Albacete, Health Service of Castilla-La Mancha (SESCAM), Albacete, SpainBiomedicine Institute of UCLM (IB-UCLM), Faculty of Medicine, University of Castilla-La Mancha, Albacete, Spain1Neurology Department, General University Hospital of Albacete, SESCAM, Albacete, Spain2Faculty of Medicine, University of Castilla-La Mancha, Albacete, SpainIntroductionDespite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since the impact of COVID-19 vaccines on the endothelium remains uncertain, our objective was to assess endothelial activation status before and 90 days after the third dose of the BNT162b2 mRNA COVID-19 vaccine.MethodsA prospective longitudinal study was conducted at University General Hospital of Albacete, involving 38 healthy health-care workers. Serum levels of endothelial markers (endocan and sVCAM-1) and spike S1-specific IgG antibodies were determined before and at 7, 15, 24 and 90days following vaccination. To analyze each participant´s individual response, we calculated relative increases/decreases (delta values) in endothelial markers and antibodies concentrations compared to their pre-vaccination levels.ResultsWe identified two significantly distinct profiles of endothelial markers response, characterized by either increased or decreased serum levels of endocan and sVCAM. Incremental and decremental response groups did not differ in terms of age, sex, cardiovascular risk factors, previous SARS-CoV-2 infection and influenza vaccine co-administration. However, these responses were significantly associated with the relative spike-specific antibody production. Specifically, the greatest relative increase in antibodies was found in the decremental responders. Additionally, the higher delta antibody production was observed in non-previously infected individualsConclusionAdministration of the BNT162b2 booster vaccine triggered a non-homogenous response of endothelial function markers among the study participants. Our findings improve the understanding of individual responses to the mRNA COVID-19 booster vaccine, which could be useful in assessing the need for booster doses, particularly in population at risk of vascular complications.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1471401/fullmRNA COVID-19 vaccinesbooster doseSARS-CoV-2anti-spike antibodiesIgGendothelial dysfunction |
| spellingShingle | Beatriz Castro-Robles Francisco J. Cimas Francisco J. Cimas Lourdes Arias-Salazar Jesús Ontañón Julia Lozano Susana López-López Fernando Andrés-Pretel María Ángeles Requena-Calleja Antonio Mas Antonio Mas Antonio Mas Gemma Serrano-Heras Tomás Segura Tomás Segura Javier Solera Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production Frontiers in Immunology mRNA COVID-19 vaccines booster dose SARS-CoV-2 anti-spike antibodies IgG endothelial dysfunction |
| title | Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production |
| title_full | Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production |
| title_fullStr | Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production |
| title_full_unstemmed | Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production |
| title_short | Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production |
| title_sort | distinct response patterns of endothelial markers to the bnt162b2 mrna covid 19 booster vaccine are associated with the spike specific igg antibody production |
| topic | mRNA COVID-19 vaccines booster dose SARS-CoV-2 anti-spike antibodies IgG endothelial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1471401/full |
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