Exosomes in neuron-glia communication: A review on neurodegeneration
Introduction: Exosomes, a subset of extracellular vesicles (EVs), are crucial for intercellular communication in various contexts. Despite their small size, they carry diverse cargo, including RNA, proteins, and lipids. Internalization by recipient cells raises concerns about potential disruptions t...
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Tabriz University of Medical Sciences
2024-09-01
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| Series: | BioImpacts |
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| Online Access: | https://bi.tbzmed.ac.ir/PDF/bi-14-30153.pdf |
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| author | Naeimeh Akbari-Gharalari Sina Khodakarimi Farshad Nezhadshahmohammad Mohammad Karimipour Abbas Ebrahimi-Kalan Jiagian Wu |
| author_facet | Naeimeh Akbari-Gharalari Sina Khodakarimi Farshad Nezhadshahmohammad Mohammad Karimipour Abbas Ebrahimi-Kalan Jiagian Wu |
| author_sort | Naeimeh Akbari-Gharalari |
| collection | DOAJ |
| description | Introduction: Exosomes, a subset of extracellular vesicles (EVs), are crucial for intercellular communication in various contexts. Despite their small size, they carry diverse cargo, including RNA, proteins, and lipids. Internalization by recipient cells raises concerns about potential disruptions to cellular functions. Notably, the ability of exosomes to traverse the blood-brain barrier (BBB) has significant implications. Methods: To conduct a thorough investigation into the existing academic literature on exosomes within the framework of neuron-glia communication, a comprehensive search strategy was implemented across the PubMed, Google Scholar, and Science Direct databases. Multiple iterations of the keywords "exosome," "neuron-glia communication," and "neurological disorders" were employed to systematically identify relevant publications. Furthermore, an exploration of the Clinicaltrials.gov database was undertaken to identify clinical trials related to cellular signaling, utilizing analogous terminology. Results: Although the immediate practical applications of exosomes are somewhat limited, their potential as carriers of pathogenic attributes offers promising opportunities for the development of precisely targeted therapeutic strategies for neurological disorders. This review presents a comprehensive overview of contemporary insights into the pivotal roles played by exosomes as agents mediating communication between neurons and glial cells within the central nervous system (CNS). Conclusion: By delving into the intricate dynamics of exosomal communication in the CNS, this review contributes to a deeper understanding of the roles of exosomes in both physiological and pathological processes, thereby paving the way for potential therapeutic advancements in the field of neurological disorders. |
| format | Article |
| id | doaj-art-2f9a2a8be8e14f78a86e44ef7c0f3fb7 |
| institution | Kabale University |
| issn | 2228-5652 2228-5660 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | BioImpacts |
| spelling | doaj-art-2f9a2a8be8e14f78a86e44ef7c0f3fb72025-01-18T10:03:41ZengTabriz University of Medical SciencesBioImpacts2228-56522228-56602024-09-01145301533015310.34172/bi.2023.30153bi-30153Exosomes in neuron-glia communication: A review on neurodegenerationNaeimeh Akbari-Gharalari0Sina Khodakarimi1Farshad Nezhadshahmohammad2Mohammad Karimipour3Abbas Ebrahimi-Kalan4Jiagian Wu5Department of Neurosciences and Cognition, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurosciences and Cognition, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Mining Engineering, Faculty of Engineering, Urmia University, Urmia, IranDepartment of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurosciences and Cognition, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranThe Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USAIntroduction: Exosomes, a subset of extracellular vesicles (EVs), are crucial for intercellular communication in various contexts. Despite their small size, they carry diverse cargo, including RNA, proteins, and lipids. Internalization by recipient cells raises concerns about potential disruptions to cellular functions. Notably, the ability of exosomes to traverse the blood-brain barrier (BBB) has significant implications. Methods: To conduct a thorough investigation into the existing academic literature on exosomes within the framework of neuron-glia communication, a comprehensive search strategy was implemented across the PubMed, Google Scholar, and Science Direct databases. Multiple iterations of the keywords "exosome," "neuron-glia communication," and "neurological disorders" were employed to systematically identify relevant publications. Furthermore, an exploration of the Clinicaltrials.gov database was undertaken to identify clinical trials related to cellular signaling, utilizing analogous terminology. Results: Although the immediate practical applications of exosomes are somewhat limited, their potential as carriers of pathogenic attributes offers promising opportunities for the development of precisely targeted therapeutic strategies for neurological disorders. This review presents a comprehensive overview of contemporary insights into the pivotal roles played by exosomes as agents mediating communication between neurons and glial cells within the central nervous system (CNS). Conclusion: By delving into the intricate dynamics of exosomal communication in the CNS, this review contributes to a deeper understanding of the roles of exosomes in both physiological and pathological processes, thereby paving the way for potential therapeutic advancements in the field of neurological disorders.https://bi.tbzmed.ac.ir/PDF/bi-14-30153.pdfexosomeneuron-glia communicationcellular signalingneurological disorders |
| spellingShingle | Naeimeh Akbari-Gharalari Sina Khodakarimi Farshad Nezhadshahmohammad Mohammad Karimipour Abbas Ebrahimi-Kalan Jiagian Wu Exosomes in neuron-glia communication: A review on neurodegeneration BioImpacts exosome neuron-glia communication cellular signaling neurological disorders |
| title | Exosomes in neuron-glia communication: A review on neurodegeneration |
| title_full | Exosomes in neuron-glia communication: A review on neurodegeneration |
| title_fullStr | Exosomes in neuron-glia communication: A review on neurodegeneration |
| title_full_unstemmed | Exosomes in neuron-glia communication: A review on neurodegeneration |
| title_short | Exosomes in neuron-glia communication: A review on neurodegeneration |
| title_sort | exosomes in neuron glia communication a review on neurodegeneration |
| topic | exosome neuron-glia communication cellular signaling neurological disorders |
| url | https://bi.tbzmed.ac.ir/PDF/bi-14-30153.pdf |
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