Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer

Abstract High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic target. Both coinhibitory and costimulatory effects of B7-H3 in tumors have been demonstrated, but the mechanism of B7-H3 immune response under dual effects is open to que...

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Bibliographic Details
Main Authors: Qi Shen, Kaichen Zhou, Haosen Lu, Jielin Zhang, Qiqing Xu, Chengsi Zhang, Chunhua Yang, Lijun Mao
Format: Article
Language:English
Published: Springer 2024-12-01
Series:Discover Oncology
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Online Access:https://doi.org/10.1007/s12672-024-01674-x
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