Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients
Background: Osteoporosis is a major problem in transfusion-dependent thalassemia patients (TDT) patients. Osteoprotegerin (OPG) is one of several bone markers that are closely associated with osteoporosis in TDT patients. OPG is a glycoprotein that functions as a feedback receptor for the Receptor...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2024-04-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | http://www.actamedindones.org/index.php/ijim/article/view/2615 |
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| author | Indra Wijaya M Lucky Nurdiansyah Prameswara Dimmy Prasetya Laniyati Hamijoyo Bachti Alisjahbana Andri Reza Rahmadi |
| author_facet | Indra Wijaya M Lucky Nurdiansyah Prameswara Dimmy Prasetya Laniyati Hamijoyo Bachti Alisjahbana Andri Reza Rahmadi |
| author_sort | Indra Wijaya |
| collection | DOAJ |
| description |
Background: Osteoporosis is a major problem in transfusion-dependent thalassemia patients (TDT) patients. Osteoprotegerin (OPG) is one of several bone markers that are closely associated with osteoporosis in TDT patients. OPG is a glycoprotein that functions as a feedback receptor for the Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), which is an alpha tumor necrosis factor receptor. One of the causes of decreased bone mass density is iron toxicity, which can be identified by showing elevated transferrin saturation. Bone mass dual X-ray absorptiometry (DEXA) is a gold standard for the diagnosis of osteoporosis, these procedures are not commonly available in Indonesia. This study was conducted to analyze the correlation between serum levels of OPG and transferrin saturation in TDT patients. Methods: A correlational study with a cross-sectional approach analyzed data from TDT patients at Hemato-Oncology Medic Outpatient Clinic, Hasan Sadikin General Hospital, Bandung, Indonesia. Primary data were obtained through blood sampling and anthropometry measurement while secondary data were obtained from the patient’s medical records. OPG and transferrin saturation levels were assessed using the ELISA method. Research data were analyzed using the rank Spearman correlation test. Results: Data were collected from 51 research subjects (30 women dan 21 men). The median OPG level was 380 (170-1230) pg/mL and the median transferrin saturation level was 89.4 (66.7 – 96.2)%. Analysis of correlation showed a significant correlation between and transferrin saturation level with a coefficient value of r -0.539 and p-value <0.001. Conclusion: There was a significant inverse correlation between OPG with transferrin saturation in TDT patients.
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| format | Article |
| id | doaj-art-2f926962a2e64362a068f6a7526e9e61 |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-2f926962a2e64362a068f6a7526e9e612025-08-20T03:11:39ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322024-04-01561Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) PatientsIndra Wijaya0M Lucky Nurdiansyah Prameswara1Dimmy Prasetya2Laniyati Hamijoyo3Bachti Alisjahbana4Andri Reza Rahmadi5Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Padjajaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Padjajaran - Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Padjajaran - Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Padjajaran - Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaDivision of Infectious and Tropical Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Padjajaran - Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Padjajaran - Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Background: Osteoporosis is a major problem in transfusion-dependent thalassemia patients (TDT) patients. Osteoprotegerin (OPG) is one of several bone markers that are closely associated with osteoporosis in TDT patients. OPG is a glycoprotein that functions as a feedback receptor for the Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), which is an alpha tumor necrosis factor receptor. One of the causes of decreased bone mass density is iron toxicity, which can be identified by showing elevated transferrin saturation. Bone mass dual X-ray absorptiometry (DEXA) is a gold standard for the diagnosis of osteoporosis, these procedures are not commonly available in Indonesia. This study was conducted to analyze the correlation between serum levels of OPG and transferrin saturation in TDT patients. Methods: A correlational study with a cross-sectional approach analyzed data from TDT patients at Hemato-Oncology Medic Outpatient Clinic, Hasan Sadikin General Hospital, Bandung, Indonesia. Primary data were obtained through blood sampling and anthropometry measurement while secondary data were obtained from the patient’s medical records. OPG and transferrin saturation levels were assessed using the ELISA method. Research data were analyzed using the rank Spearman correlation test. Results: Data were collected from 51 research subjects (30 women dan 21 men). The median OPG level was 380 (170-1230) pg/mL and the median transferrin saturation level was 89.4 (66.7 – 96.2)%. Analysis of correlation showed a significant correlation between and transferrin saturation level with a coefficient value of r -0.539 and p-value <0.001. Conclusion: There was a significant inverse correlation between OPG with transferrin saturation in TDT patients. http://www.actamedindones.org/index.php/ijim/article/view/2615OPGtransferrin saturationosteoporosistransfusion-dependent thalassemia |
| spellingShingle | Indra Wijaya M Lucky Nurdiansyah Prameswara Dimmy Prasetya Laniyati Hamijoyo Bachti Alisjahbana Andri Reza Rahmadi Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients Acta Medica Indonesiana OPG transferrin saturation osteoporosis transfusion-dependent thalassemia |
| title | Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients |
| title_full | Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients |
| title_fullStr | Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients |
| title_full_unstemmed | Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients |
| title_short | Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients |
| title_sort | significant inverse correlation of serum levels of osteoprotegerin opg and transferrin saturation in thalassemia dependent transfusion tdt patients |
| topic | OPG transferrin saturation osteoporosis transfusion-dependent thalassemia |
| url | http://www.actamedindones.org/index.php/ijim/article/view/2615 |
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