The Meanings of Alzheimer’s Disease
Alzheimer’s disease emerged around the 1900s as a rare disease that became synonymous with common dementia by the 1980s. In the 2010s, in vivo biomarkers of Alzheimer’s pathophysiology then led researchers to emphasize the presymptomatic biology of Alzheimer’s biomarkers, thus decentering dementia....
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2025-05-01
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| Series: | Philosophy of Medicine |
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| Online Access: | http://philmed.pitt.edu/philmed/article/view/251 |
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| author | Timothy Daly |
| author_facet | Timothy Daly |
| author_sort | Timothy Daly |
| collection | DOAJ |
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Alzheimer’s disease emerged around the 1900s as a rare disease that became synonymous with common dementia by the 1980s. In the 2010s, in vivo biomarkers of Alzheimer’s pathophysiology then led researchers to emphasize the presymptomatic biology of Alzheimer’s biomarkers, thus decentering dementia. Three consensus definitions were elaborated around biomarkers, and were rearticulated in 2024: biomarker-determined Alzheimer’s disease; biomarker-informed “clinical-biological” Alzheimer’s disease; and biomarker-independent, “all-cause” dementia. I consider their differences to hinge on the questionable legitimacy of the Alzheimer “biomarkerization” of aging. I encourage a focus on the actionable concept of brain health beyond Alzheimer’s to motivate equitable health promotion.
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| format | Article |
| id | doaj-art-2f8c60c291b7411da9b37cb1289c2f33 |
| institution | Kabale University |
| issn | 2692-3963 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | Philosophy of Medicine |
| spelling | doaj-art-2f8c60c291b7411da9b37cb1289c2f332025-08-20T03:52:52ZengUniversity Library System, University of PittsburghPhilosophy of Medicine2692-39632025-05-016110.5195/pom.2025.251The Meanings of Alzheimer’s DiseaseTimothy Daly0https://orcid.org/0000-0003-1650-242XUMR 1219 (Bordeaux Population Health), University of Bordeaux & INSERM, Bordeaux, France; UMR 5164 (ImmunoConcept), University of Bordeaux & CNRS, Bordeaux, France; Bioethics Program, FLACSO Argentina, Buenos Aires, Argentina Alzheimer’s disease emerged around the 1900s as a rare disease that became synonymous with common dementia by the 1980s. In the 2010s, in vivo biomarkers of Alzheimer’s pathophysiology then led researchers to emphasize the presymptomatic biology of Alzheimer’s biomarkers, thus decentering dementia. Three consensus definitions were elaborated around biomarkers, and were rearticulated in 2024: biomarker-determined Alzheimer’s disease; biomarker-informed “clinical-biological” Alzheimer’s disease; and biomarker-independent, “all-cause” dementia. I consider their differences to hinge on the questionable legitimacy of the Alzheimer “biomarkerization” of aging. I encourage a focus on the actionable concept of brain health beyond Alzheimer’s to motivate equitable health promotion. http://philmed.pitt.edu/philmed/article/view/251Alzheimer's diseaseConcepts of health and diseasePublic health |
| spellingShingle | Timothy Daly The Meanings of Alzheimer’s Disease Philosophy of Medicine Alzheimer's disease Concepts of health and disease Public health |
| title | The Meanings of Alzheimer’s Disease |
| title_full | The Meanings of Alzheimer’s Disease |
| title_fullStr | The Meanings of Alzheimer’s Disease |
| title_full_unstemmed | The Meanings of Alzheimer’s Disease |
| title_short | The Meanings of Alzheimer’s Disease |
| title_sort | meanings of alzheimer s disease |
| topic | Alzheimer's disease Concepts of health and disease Public health |
| url | http://philmed.pitt.edu/philmed/article/view/251 |
| work_keys_str_mv | AT timothydaly themeaningsofalzheimersdisease AT timothydaly meaningsofalzheimersdisease |