Current principles of symptomatic treatment of lymphovenous insufficiency
This article provides a review of the current literature on the current principles of symptomatic treatment of lymphovenous insufficiency. Lymphovenous insufficiency is an urgent problem of modern phlebology, the prevalence of this pathology reaches 50% among the world population. Underlying the pat...
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| Language: | Russian |
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Remedium Group LTD
2023-05-01
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| Series: | Амбулаторная хирургия |
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| Online Access: | https://www.a-surgeon.ru/jour/article/view/348 |
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| author | S. S. Dunaevskaya |
| author_facet | S. S. Dunaevskaya |
| author_sort | S. S. Dunaevskaya |
| collection | DOAJ |
| description | This article provides a review of the current literature on the current principles of symptomatic treatment of lymphovenous insufficiency. Lymphovenous insufficiency is an urgent problem of modern phlebology, the prevalence of this pathology reaches 50% among the world population. Underlying the pathogenesis is venous hypertension, which is caused by venous valve insufficiency, venous outflow obstruction, or combined causes. The use of compression knitwear and symptomatic therapy for lymphovenous insufficiency is an important component of the treatment at the initial stages of the disease — pharmacotherapy based on the use of venoactive drugs. The most promising to date are preparations of the micronized purified flavonide fraction (MPFF) group, which consist of micronized diosmin and flavonides. The use of МОФФ drugs reduces venous hypertension by increasing venous tone, reducing venous capacity, and extensibility of the vessel wall. MPFF also improves lymph conversion by increasing the contractility of the lymphatic capillaries and has an effect on the microcirculation of the vessels of the lower extremities, having an effect on the resistance and permeability of the capillaries. Thus, the use of preparations of the micronized purified fraction of flavonides has a more pronounced effect on the etiology and pathogenesis of the disease, thereby increasing the clinical effect and leading to a more effective result in the treatment of lymphovenous insufficiency. And as presented in this review, drugs containing micronized purified flavonoid fraction are an excellent candidate to be further studied as therapeutic agents for the treatment of lymphovenous insufficiency, because the mechanism of action of the micronized purified flavonoid fraction is directly connected with its pathophysiology and high clinical efficacy. |
| format | Article |
| id | doaj-art-2f86ba097beb44cb9a7db9f11eed0755 |
| institution | DOAJ |
| issn | 2712-8741 2782-2591 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Remedium Group LTD |
| record_format | Article |
| series | Амбулаторная хирургия |
| spelling | doaj-art-2f86ba097beb44cb9a7db9f11eed07552025-08-20T03:05:27ZrusRemedium Group LTDАмбулаторная хирургия2712-87412782-25912023-05-01201444910.21518/akh2022-004289Current principles of symptomatic treatment of lymphovenous insufficiencyS. S. Dunaevskaya0Krasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyThis article provides a review of the current literature on the current principles of symptomatic treatment of lymphovenous insufficiency. Lymphovenous insufficiency is an urgent problem of modern phlebology, the prevalence of this pathology reaches 50% among the world population. Underlying the pathogenesis is venous hypertension, which is caused by venous valve insufficiency, venous outflow obstruction, or combined causes. The use of compression knitwear and symptomatic therapy for lymphovenous insufficiency is an important component of the treatment at the initial stages of the disease — pharmacotherapy based on the use of venoactive drugs. The most promising to date are preparations of the micronized purified flavonide fraction (MPFF) group, which consist of micronized diosmin and flavonides. The use of МОФФ drugs reduces venous hypertension by increasing venous tone, reducing venous capacity, and extensibility of the vessel wall. MPFF also improves lymph conversion by increasing the contractility of the lymphatic capillaries and has an effect on the microcirculation of the vessels of the lower extremities, having an effect on the resistance and permeability of the capillaries. Thus, the use of preparations of the micronized purified fraction of flavonides has a more pronounced effect on the etiology and pathogenesis of the disease, thereby increasing the clinical effect and leading to a more effective result in the treatment of lymphovenous insufficiency. And as presented in this review, drugs containing micronized purified flavonoid fraction are an excellent candidate to be further studied as therapeutic agents for the treatment of lymphovenous insufficiency, because the mechanism of action of the micronized purified flavonoid fraction is directly connected with its pathophysiology and high clinical efficacy.https://www.a-surgeon.ru/jour/article/view/348venous lymphatic insufficiencyvenous hypertensionsymptomatic treatmentmicronized purified flavonide fractioncompression |
| spellingShingle | S. S. Dunaevskaya Current principles of symptomatic treatment of lymphovenous insufficiency Амбулаторная хирургия venous lymphatic insufficiency venous hypertension symptomatic treatment micronized purified flavonide fraction compression |
| title | Current principles of symptomatic treatment of lymphovenous insufficiency |
| title_full | Current principles of symptomatic treatment of lymphovenous insufficiency |
| title_fullStr | Current principles of symptomatic treatment of lymphovenous insufficiency |
| title_full_unstemmed | Current principles of symptomatic treatment of lymphovenous insufficiency |
| title_short | Current principles of symptomatic treatment of lymphovenous insufficiency |
| title_sort | current principles of symptomatic treatment of lymphovenous insufficiency |
| topic | venous lymphatic insufficiency venous hypertension symptomatic treatment micronized purified flavonide fraction compression |
| url | https://www.a-surgeon.ru/jour/article/view/348 |
| work_keys_str_mv | AT ssdunaevskaya currentprinciplesofsymptomatictreatmentoflymphovenousinsufficiency |