Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus
Objectives This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM).Methods Twenty-six GDM patients aged between 22 and 35 years and 25 healthy pregnant wom...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2022.2164762 |
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| author | Hongmei Zhang# Zhigao Chen# Xiaoling Wang |
| author_facet | Hongmei Zhang# Zhigao Chen# Xiaoling Wang |
| author_sort | Hongmei Zhang# |
| collection | DOAJ |
| description | Objectives This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM).Methods Twenty-six GDM patients aged between 22 and 35 years and 25 healthy pregnant women aged between 23 and 34 years were recruited. Maternal serum levels of KLF2, KLF4, and their target proteins sP-selectin, sE-selectin were measured using enzyme-linked immunosorbent assays at 24–28 weeks of gestation.Results Women with GDM had significantly lower serum KLF2 than controls. However, the differences in levels of serum KLF4 between the control and GDM groups were not significant. Additionally, elevated serum sP-selectin and sE-selectin were found in the GDM group and not in the healthy group. Importantly, we also found that serum KLF2 levels were negatively correlated with indicators of glucose metabolism, including insulin, fasting blood glucose, 1-h oral glucose tolerance test, and glycated hemoglobin.Conclusion We conclude that (i) serum KLF2 might be indicative of GDM risk, and (ii) sP-selectin and sE-selectin were increased in GDM patients. |
| format | Article |
| id | doaj-art-2f838f5846fc4282a6b4a1ff9bbda386 |
| institution | OA Journals |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-2f838f5846fc4282a6b4a1ff9bbda3862025-08-20T02:18:42ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662022-12-0138121121112410.1080/09513590.2022.2164762Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitusHongmei Zhang#0Zhigao Chen#1Xiaoling Wang2Department of Obstetrics, Hanchuan People’s Hospital, Hanchuan City, Xiaogan City, Hubei Province, ChinaDepartment of Obstetrics, Hanchuan People’s Hospital, Hanchuan City, Xiaogan City, Hubei Province, ChinaDepartment of Obstetrics, Hanchuan People’s Hospital, Hanchuan City, Xiaogan City, Hubei Province, ChinaObjectives This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM).Methods Twenty-six GDM patients aged between 22 and 35 years and 25 healthy pregnant women aged between 23 and 34 years were recruited. Maternal serum levels of KLF2, KLF4, and their target proteins sP-selectin, sE-selectin were measured using enzyme-linked immunosorbent assays at 24–28 weeks of gestation.Results Women with GDM had significantly lower serum KLF2 than controls. However, the differences in levels of serum KLF4 between the control and GDM groups were not significant. Additionally, elevated serum sP-selectin and sE-selectin were found in the GDM group and not in the healthy group. Importantly, we also found that serum KLF2 levels were negatively correlated with indicators of glucose metabolism, including insulin, fasting blood glucose, 1-h oral glucose tolerance test, and glycated hemoglobin.Conclusion We conclude that (i) serum KLF2 might be indicative of GDM risk, and (ii) sP-selectin and sE-selectin were increased in GDM patients.https://www.tandfonline.com/doi/10.1080/09513590.2022.2164762Gestational diabetes mellitusKrüppel-like factor-2Krüppel-like factor-4oral glucose tolerance testpregnancysE-selectin |
| spellingShingle | Hongmei Zhang# Zhigao Chen# Xiaoling Wang Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus Gynecological Endocrinology Gestational diabetes mellitus Krüppel-like factor-2 Krüppel-like factor-4 oral glucose tolerance test pregnancy sE-selectin |
| title | Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus |
| title_full | Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus |
| title_fullStr | Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus |
| title_full_unstemmed | Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus |
| title_short | Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus |
| title_sort | differentiated serum levels of kruppel like factors 2 and 4 sp selectin and se selectin in patients with gestational diabetes mellitus |
| topic | Gestational diabetes mellitus Krüppel-like factor-2 Krüppel-like factor-4 oral glucose tolerance test pregnancy sE-selectin |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2022.2164762 |
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