Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors

Mycobacterium ulcerans is the causative agent of Buruli ulcer – a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in M. marinum, it is likely that M. ulcerans employs sporulation mechanisms for its sur...

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Main Authors: Eunice Ampadubea Ayerakwa, Molly Kukua Abban, Abiola Isawumi, Lydia Mosi
Format: Article
Language:English
Published: Taylor & Francis Group 2023-03-01
Series:Future Science OA
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Online Access:https://www.future-science.com/doi/10.2144/fsoa-2022-0044
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author Eunice Ampadubea Ayerakwa
Molly Kukua Abban
Abiola Isawumi
Lydia Mosi
author_facet Eunice Ampadubea Ayerakwa
Molly Kukua Abban
Abiola Isawumi
Lydia Mosi
author_sort Eunice Ampadubea Ayerakwa
collection DOAJ
description Mycobacterium ulcerans is the causative agent of Buruli ulcer – a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in M. marinum, it is likely that M. ulcerans employs sporulation mechanisms for its survival and transmission. In this review, we modeled possible transmission routes and patterns of M. ulcerans from the environment to its host. We provided insights into the evolution of M. ulcerans and its genomic profiles. We discuss reservoirs of M. ulcerans as an environmental pathogen and its environmental survival. We comprehensively discuss sporulation as a possible stress response mechanism and modelled endospore formation in M. ulcerans. At last, we highlighted sporulation associated markers, which upon expression trigger endospore formation.
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spelling doaj-art-2f80703a67034c6096b6101a3dcd92d22025-08-20T02:25:50ZengTaylor & Francis GroupFuture Science OA2056-56232023-03-019310.2144/fsoa-2022-0044Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factorsEunice Ampadubea Ayerakwa0Molly Kukua Abban1Abiola Isawumi2Lydia Mosi31West African Centre for Cell Biology of Infectious Pathogens, LG 54 Volta Road, University of Ghana, Legon Accra, Ghana1West African Centre for Cell Biology of Infectious Pathogens, LG 54 Volta Road, University of Ghana, Legon Accra, Ghana1West African Centre for Cell Biology of Infectious Pathogens, LG 54 Volta Road, University of Ghana, Legon Accra, Ghana1West African Centre for Cell Biology of Infectious Pathogens, LG 54 Volta Road, University of Ghana, Legon Accra, GhanaMycobacterium ulcerans is the causative agent of Buruli ulcer – a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in M. marinum, it is likely that M. ulcerans employs sporulation mechanisms for its survival and transmission. In this review, we modeled possible transmission routes and patterns of M. ulcerans from the environment to its host. We provided insights into the evolution of M. ulcerans and its genomic profiles. We discuss reservoirs of M. ulcerans as an environmental pathogen and its environmental survival. We comprehensively discuss sporulation as a possible stress response mechanism and modelled endospore formation in M. ulcerans. At last, we highlighted sporulation associated markers, which upon expression trigger endospore formation.https://www.future-science.com/doi/10.2144/fsoa-2022-0044Buruli ulcerenvironmental pathogenmycobacteriaMycobacteria ulceranssporulationstress response mechanisms
spellingShingle Eunice Ampadubea Ayerakwa
Molly Kukua Abban
Abiola Isawumi
Lydia Mosi
Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors
Future Science OA
Buruli ulcer
environmental pathogen
mycobacteria
Mycobacteria ulcerans
sporulation
stress response mechanisms
title Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors
title_full Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors
title_fullStr Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors
title_full_unstemmed Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors
title_short Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors
title_sort profiling mycobacterium ulcerans sporulation survival strategy and response to environmental factors
topic Buruli ulcer
environmental pathogen
mycobacteria
Mycobacteria ulcerans
sporulation
stress response mechanisms
url https://www.future-science.com/doi/10.2144/fsoa-2022-0044
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AT abiolaisawumi profilingmycobacteriumulceranssporulationsurvivalstrategyandresponsetoenvironmentalfactors
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