Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression
ABSTRACT Background: Among the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS. Obje...
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Thieme Revinter Publicações
2022-02-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022005003202&tlng=en |
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| author | Serhan SEVIM Meltem DEMIRKIRAN Murat TERZI Nur YÜCEYAR Bahar TAŞDELEN Egemen İDIMAN Murat KÜRTÜNCÜ Cavit BOZ Deniz TUNCEL Rana KARABUDAK Aksel SIVA Abdülcemal ÖZCAN Münife NEYAL Başak Karakurum GÖKSEL Gülcan Baran GAZALOĞLU Mehmet BALAL Sedat ŞEN Meltem Alkaya BAKLAN Tuncay GÜNDÜZ Aslı TUNCER Uğur UYGUNOĞLU |
| author_facet | Serhan SEVIM Meltem DEMIRKIRAN Murat TERZI Nur YÜCEYAR Bahar TAŞDELEN Egemen İDIMAN Murat KÜRTÜNCÜ Cavit BOZ Deniz TUNCEL Rana KARABUDAK Aksel SIVA Abdülcemal ÖZCAN Münife NEYAL Başak Karakurum GÖKSEL Gülcan Baran GAZALOĞLU Mehmet BALAL Sedat ŞEN Meltem Alkaya BAKLAN Tuncay GÜNDÜZ Aslı TUNCER Uğur UYGUNOĞLU |
| author_sort | Serhan SEVIM |
| collection | DOAJ |
| description | ABSTRACT Background: Among the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS. Objective: To investigate the psychiatric burden of MS and RLS coexistence, we conducted a nationwide, multicenter and cross-sectional survey. Methods: Participants were assessed by using demographic and clinical parameters along with the Hamilton Anxiety and Hamilton Depression Scales (HAM-A and HAM-D). Results: Out of the 1,068 participants, 173 (16.2%) were found to have RLS [RLS(+)] and 895 (83.8%) did not [RLS(-)]. The mean scores for HAM-A and HAM-D were significantly higher among RLS(+) subjects than among RLS(-) subjects (p<0.001 for all variables). Conclusions: According to our data, the presence of RLS in PwMS may increase the occurrence of both anxiety and depression symptoms. Awareness and treatment of RLS in PwMS could possibly reduce the symptoms of psychiatric comorbidities originating from RLS. |
| format | Article |
| id | doaj-art-2f8057e848924eaeb4a0fadf00c14a31 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-2f8057e848924eaeb4a0fadf00c14a312025-08-20T02:01:47ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272022-02-0110.1590/0004-282x-anp-2020-0400Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depressionSerhan SEVIMhttps://orcid.org/0000-0002-0518-3374Meltem DEMIRKIRANhttps://orcid.org/0000-0002-4649-5315Murat TERZIhttps://orcid.org/0000-0002-3586-9115Nur YÜCEYARhttps://orcid.org/0000-0003-4590-6423Bahar TAŞDELENhttps://orcid.org/0000-0001-8146-4912Egemen İDIMANhttps://orcid.org/0000-0003-1359-8251Murat KÜRTÜNCÜhttps://orcid.org/0000-0003-3286-2652Cavit BOZhttps://orcid.org/0000-0003-0956-3304Deniz TUNCELhttps://orcid.org/0000-0003-2347-472XRana KARABUDAKhttps://orcid.org/0000-0003-4272-1482Aksel SIVAhttps://orcid.org/0000-0002-8340-6641Abdülcemal ÖZCANhttps://orcid.org/0000-0002-6759-7556Münife NEYALhttps://orcid.org/0000-0001-7864-9166Başak Karakurum GÖKSELhttps://orcid.org/0000-0003-2766-2277Gülcan Baran GAZALOĞLUhttps://orcid.org/0000-0001-6687-5211Mehmet BALALhttps://orcid.org/0000-0001-8320-6597Sedat ŞENhttps://orcid.org/0000-0001-8048-6845Meltem Alkaya BAKLANhttps://orcid.org/0000-0001-7953-0378Tuncay GÜNDÜZhttps://orcid.org/0000-0003-4241-0908Aslı TUNCERhttps://orcid.org/0000-0001-9449-4483Uğur UYGUNOĞLUhttps://orcid.org/0000-0003-2866-4004ABSTRACT Background: Among the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS. Objective: To investigate the psychiatric burden of MS and RLS coexistence, we conducted a nationwide, multicenter and cross-sectional survey. Methods: Participants were assessed by using demographic and clinical parameters along with the Hamilton Anxiety and Hamilton Depression Scales (HAM-A and HAM-D). Results: Out of the 1,068 participants, 173 (16.2%) were found to have RLS [RLS(+)] and 895 (83.8%) did not [RLS(-)]. The mean scores for HAM-A and HAM-D were significantly higher among RLS(+) subjects than among RLS(-) subjects (p<0.001 for all variables). Conclusions: According to our data, the presence of RLS in PwMS may increase the occurrence of both anxiety and depression symptoms. Awareness and treatment of RLS in PwMS could possibly reduce the symptoms of psychiatric comorbidities originating from RLS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022005003202&tlng=enMultiple SclerosisRestless Legs SyndromeDepressionAnxietyMental Disorders |
| spellingShingle | Serhan SEVIM Meltem DEMIRKIRAN Murat TERZI Nur YÜCEYAR Bahar TAŞDELEN Egemen İDIMAN Murat KÜRTÜNCÜ Cavit BOZ Deniz TUNCEL Rana KARABUDAK Aksel SIVA Abdülcemal ÖZCAN Münife NEYAL Başak Karakurum GÖKSEL Gülcan Baran GAZALOĞLU Mehmet BALAL Sedat ŞEN Meltem Alkaya BAKLAN Tuncay GÜNDÜZ Aslı TUNCER Uğur UYGUNOĞLU Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression Arquivos de Neuro-Psiquiatria Multiple Sclerosis Restless Legs Syndrome Depression Anxiety Mental Disorders |
| title | Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression |
| title_full | Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression |
| title_fullStr | Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression |
| title_full_unstemmed | Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression |
| title_short | Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression |
| title_sort | coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression |
| topic | Multiple Sclerosis Restless Legs Syndrome Depression Anxiety Mental Disorders |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022005003202&tlng=en |
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