Effect of oral sodium bicarbonate supplementation on urine TGF-𝜷 in normal serum bicarbonate CKD, a randomized controlled trial

Effect of oral sodium bicarbonate supplementation on urine TGF-𝜷 in normal serum bicarbonate CKD, a randomized controlled trial

Abstract The consequences of chronic subclinical metabolic acidosis, characterized by an increase in single nephron ammonium generation, contribute to the progression of chronic kidney disease (CKD). Therefore, sodium bicarbonate (NaHCO₃) supplementation in CKD with normal serum bicarbonate patients...

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Bibliographic Details
Main Authors: Nipon Ngupis, Bancha Satirapoj, Theerasak Tangwonglert, Ouppatham Supasyndh, Paramat Thimachai, Narongrit Siriwattanasit
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Subclinical metabolic acidosis
Chronic kidney disease
Urinary TGF-β
Online Access:https://doi.org/10.1038/s41598-025-03733-x
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