Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy.

Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy.

Treating macaques with an anti-α4β7 antibody under the umbrella of combination antiretroviral therapy (cART) during early SIV infection can lead to viral remission, with viral loads maintained at < 50 SIV RNA copies/ml after removal of all treatment in a subset of animals. Depletion of CD8+ lymph...

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Bibliographic Details
Main Authors: Chad R Wells, Youfang Cao, David P Durham, Siddappa N Byrareddy, Aftab A Ansari, Nancy H Ruddle, Jeffrey P Townsend, Alison P Galvani, Alan S Perelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-06-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189501
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