Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice

Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice

Objectives: Creatine kinase B (CKB) is the main isoenzyme driving creatine kinase (CK) activity in classical brown adipocytes. However, the specific CK isoenzyme active in beige adipocytes remains unknown. This study aimed to identify the predominant CK isoenzyme expressed and functionally active in...

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Bibliographic Details
Main Authors: Jakub Bunk, Mina Ersin, Mohammed F. Hussain, Bozena Samborska, Maria Guerra-Martinez, Drishti Soni, Lawrence Kazak
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
UCP1-indpendent thermogenesis
Futile Creatine Cycle
Creatine Kinase B
Tissue-nonspecific alkaline phosphatase
Beige adipocytes
Isotope tracing
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001000
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