Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence
This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was cond...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Japanese Dental Science Review |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761625000110 |
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| author | Kunhua Yang Alexander Patera Nugraha Junduo Chen Hui Yang Jingyu Wang Juan Ramón Vanegas Sáenz Guang Hong |
| author_facet | Kunhua Yang Alexander Patera Nugraha Junduo Chen Hui Yang Jingyu Wang Juan Ramón Vanegas Sáenz Guang Hong |
| author_sort | Kunhua Yang |
| collection | DOAJ |
| description | This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was conducted using MEDLINE/PubMed, Scopus, Web of Science, Scopus, and Embase for English-language publications with no date restrictions, yielding 180 publications. After removing duplicates, 150 remained, from which 23 were evaluated in full. 17 in vitro studies met the inclusion criteria, of which 13 had a low risk of bias, 4 had a moderate risk, and none had a high risk. Across all included investigations, CNF consistently improved mechanical performance, particularly flexural and compressive strength, while maintaining or enhancing biocompatibility in various cell culture models. CNF’s nanofibrillar structure and modifiable surface chemistry also expanded its functional versatility, enabling applications such as drug encapsulation and targeted antimicrobial delivery. Overall, CNF emerges as a promising biomaterial for modern dentistry, offering superior mechanical reinforcement, favorable cell responses, and wide-ranging functional modifications. Further in vivo research and clinical trials are necessary to confirm its long-term safety and efficacy, thereby facilitating the translation of these in vitro findings into standard dental practice. |
| format | Article |
| id | doaj-art-2f7023e90ba94c23a09cff8abed11278 |
| institution | DOAJ |
| issn | 1882-7616 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj-art-2f7023e90ba94c23a09cff8abed112782025-08-20T03:20:20ZengElsevierJapanese Dental Science Review1882-76162025-12-016110311110.1016/j.jdsr.2025.05.002Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidenceKunhua Yang0Alexander Patera Nugraha1Junduo Chen2Hui Yang3Jingyu Wang4Juan Ramón Vanegas Sáenz5Guang Hong6Division for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, JapanDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan; Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, IndonesiaDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, JapanDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, JapanState Key Laboratory of Oral & Max Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, JapanDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan; Correspondence to: 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was conducted using MEDLINE/PubMed, Scopus, Web of Science, Scopus, and Embase for English-language publications with no date restrictions, yielding 180 publications. After removing duplicates, 150 remained, from which 23 were evaluated in full. 17 in vitro studies met the inclusion criteria, of which 13 had a low risk of bias, 4 had a moderate risk, and none had a high risk. Across all included investigations, CNF consistently improved mechanical performance, particularly flexural and compressive strength, while maintaining or enhancing biocompatibility in various cell culture models. CNF’s nanofibrillar structure and modifiable surface chemistry also expanded its functional versatility, enabling applications such as drug encapsulation and targeted antimicrobial delivery. Overall, CNF emerges as a promising biomaterial for modern dentistry, offering superior mechanical reinforcement, favorable cell responses, and wide-ranging functional modifications. Further in vivo research and clinical trials are necessary to confirm its long-term safety and efficacy, thereby facilitating the translation of these in vitro findings into standard dental practice.http://www.sciencedirect.com/science/article/pii/S1882761625000110Cellulose nanofiberDental materialBiocompatibilityMechanical propertiesIn vitro studies |
| spellingShingle | Kunhua Yang Alexander Patera Nugraha Junduo Chen Hui Yang Jingyu Wang Juan Ramón Vanegas Sáenz Guang Hong Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence Japanese Dental Science Review Cellulose nanofiber Dental material Biocompatibility Mechanical properties In vitro studies |
| title | Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence |
| title_full | Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence |
| title_fullStr | Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence |
| title_full_unstemmed | Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence |
| title_short | Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence |
| title_sort | utilization of cellulose nanofiber in dental applications a systematic review of in vitro evidence |
| topic | Cellulose nanofiber Dental material Biocompatibility Mechanical properties In vitro studies |
| url | http://www.sciencedirect.com/science/article/pii/S1882761625000110 |
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