Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters
Abstract Flow diverters (FDs) have been employed in the treatment of unruptured intracranial vertebral artery dissecting aneurysms (IVADAs), yielding seemingly favorable outcomes. Despite FD treatment, aneurysm persistence (incomplete occlusion post-initial treatment) can occur in some patients, pot...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-98737-y |
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| author | Jiangli Han Xiaobo Li Hao Niu Long Lin Aihua Liu Ying Xia |
| author_facet | Jiangli Han Xiaobo Li Hao Niu Long Lin Aihua Liu Ying Xia |
| author_sort | Jiangli Han |
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| description | Abstract Flow diverters (FDs) have been employed in the treatment of unruptured intracranial vertebral artery dissecting aneurysms (IVADAs), yielding seemingly favorable outcomes. Despite FD treatment, aneurysm persistence (incomplete occlusion post-initial treatment) can occur in some patients, potentially leading to recurrent symptoms or complications. This study aims to explore the risk factors associated with the persistence of unruptured IVADAs that have undergone treatment with FDs. The study encompassed 77 unruptured IVADAs from 75 consecutive patients who received treatment with FDs. At a median follow-up of 13 months, 31.2% (24/77) of IVADAs exhibited persistence. Upon multivariate logistic regression analysis, significant pre-procedural stenosis adjacent to aneurysmal dilatation (odds ratio [OR] 17.02, 95% confidence interval [CI] 2.01–144.24, p = 0.009) and posterior inferior cerebellar artery involvement (OR 7.06, 95% CI 1.40–35.50, p = 0.018) were independently associated with aneurysm persistence; while follow-up duration (OR 0.91, 95% CI 0.84–0.97, p = 0.005) was adversely associated with aneurysm persistence. Significant pre-procedural stenosis adjacent to aneurysmal dilatation and posterior inferior cerebellar artery involvement could serve as independent risk factors contributing to the persistence of unruptured IVADAs after FD treatment. . |
| format | Article |
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| spelling | doaj-art-2f6fa6b6141a42feb904e775a0d786032025-08-20T03:13:54ZengNature PortfolioScientific Reports2045-23222025-04-011511610.1038/s41598-025-98737-yRisk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow divertersJiangli Han0Xiaobo Li1Hao Niu2Long Lin3Aihua Liu4Ying Xia5Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South UniversityDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South UniversityBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South UniversityBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South UniversityAbstract Flow diverters (FDs) have been employed in the treatment of unruptured intracranial vertebral artery dissecting aneurysms (IVADAs), yielding seemingly favorable outcomes. Despite FD treatment, aneurysm persistence (incomplete occlusion post-initial treatment) can occur in some patients, potentially leading to recurrent symptoms or complications. This study aims to explore the risk factors associated with the persistence of unruptured IVADAs that have undergone treatment with FDs. The study encompassed 77 unruptured IVADAs from 75 consecutive patients who received treatment with FDs. At a median follow-up of 13 months, 31.2% (24/77) of IVADAs exhibited persistence. Upon multivariate logistic regression analysis, significant pre-procedural stenosis adjacent to aneurysmal dilatation (odds ratio [OR] 17.02, 95% confidence interval [CI] 2.01–144.24, p = 0.009) and posterior inferior cerebellar artery involvement (OR 7.06, 95% CI 1.40–35.50, p = 0.018) were independently associated with aneurysm persistence; while follow-up duration (OR 0.91, 95% CI 0.84–0.97, p = 0.005) was adversely associated with aneurysm persistence. Significant pre-procedural stenosis adjacent to aneurysmal dilatation and posterior inferior cerebellar artery involvement could serve as independent risk factors contributing to the persistence of unruptured IVADAs after FD treatment. .https://doi.org/10.1038/s41598-025-98737-yDissecting aneurysmFlow diverterStenosisTherapeutic occlusionVertebral artery |
| spellingShingle | Jiangli Han Xiaobo Li Hao Niu Long Lin Aihua Liu Ying Xia Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters Scientific Reports Dissecting aneurysm Flow diverter Stenosis Therapeutic occlusion Vertebral artery |
| title | Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters |
| title_full | Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters |
| title_fullStr | Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters |
| title_full_unstemmed | Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters |
| title_short | Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters |
| title_sort | risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters |
| topic | Dissecting aneurysm Flow diverter Stenosis Therapeutic occlusion Vertebral artery |
| url | https://doi.org/10.1038/s41598-025-98737-y |
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