Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
A two-year-old girl with congenital dyserythropoietic anemia (CDA) acutely developed fever, tachypnea, and increased oxygen requirement. Chest X-ray revealed bilateral interstitial infiltrates and mild cardiomegaly. Blood cultures grew no infectious agents, while pulmonary specimens grew cytomegalov...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/624740 |
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| _version_ | 1850216880343613440 |
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| author | Marcus A. Carden Ashish Barman Gita Massey |
| author_facet | Marcus A. Carden Ashish Barman Gita Massey |
| author_sort | Marcus A. Carden |
| collection | DOAJ |
| description | A two-year-old girl with congenital dyserythropoietic anemia (CDA) acutely developed fever, tachypnea, and increased oxygen requirement. Chest X-ray revealed bilateral interstitial infiltrates and mild cardiomegaly. Blood cultures grew no infectious agents, while pulmonary specimens grew cytomegalovirus (CMV). Treatment with intravenous ganciclovir was initiated but without response. Final cytologic preparations of bronchoalveolar lavage (BAL) fluid revealed eosinophilic amorphous material consistent with pulmonary alveolar proteinosis (PAP). CDA and PAP are extremely rare disorders in pediatrics. PAP should be considered in patients with hematological disorders who present with acute interstitial pneumonia, after infectious causes are ruled out. |
| format | Article |
| id | doaj-art-2f6de53b9be8413a826b6739ef82f809 |
| institution | OA Journals |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-2f6de53b9be8413a826b6739ef82f8092025-08-20T02:08:12ZengWileyCase Reports in Pediatrics2090-68032090-68112012-01-01201210.1155/2012/624740624740Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case ReportMarcus A. Carden0Ashish Barman1Gita Massey2Departments of Internal Medicine and Pediatrics, Virginia Commonwealth University, 1001 East Marshall Street, Richmond, VA 23298-0646, USADivision of Anatomic Pathology, Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298-0646, USADivision of Pediatric Hematology and Oncology, Department of Pediatrics, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA 23298-0646, USAA two-year-old girl with congenital dyserythropoietic anemia (CDA) acutely developed fever, tachypnea, and increased oxygen requirement. Chest X-ray revealed bilateral interstitial infiltrates and mild cardiomegaly. Blood cultures grew no infectious agents, while pulmonary specimens grew cytomegalovirus (CMV). Treatment with intravenous ganciclovir was initiated but without response. Final cytologic preparations of bronchoalveolar lavage (BAL) fluid revealed eosinophilic amorphous material consistent with pulmonary alveolar proteinosis (PAP). CDA and PAP are extremely rare disorders in pediatrics. PAP should be considered in patients with hematological disorders who present with acute interstitial pneumonia, after infectious causes are ruled out.http://dx.doi.org/10.1155/2012/624740 |
| spellingShingle | Marcus A. Carden Ashish Barman Gita Massey Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report Case Reports in Pediatrics |
| title | Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report |
| title_full | Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report |
| title_fullStr | Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report |
| title_full_unstemmed | Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report |
| title_short | Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report |
| title_sort | pulmonary alveolar proteinosis in association with congenital dyserythropoietic anemia a case report |
| url | http://dx.doi.org/10.1155/2012/624740 |
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