Pharmacogenetics of schizophrenia in real clinical practice: a clinical case
Schizophrenia is a socially significant mental disorder characterized by early onset and high time and financial expenditure on treatment. The basic drugs in these patients are antipsychotics that are highly effective against the positive and negative symptoms of schizophrenia, but at the same time...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-12-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/1002 |
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| author | R. F. Nasyrova N. A. Schnaider K. O. Mironov G. A. Shipulin O. P. Dribnokhodova E. A. Golosov M. Yu. Tolmachev B. V. Andreev A. A. Kurylev L. Sh. Akhmetova О. V. Limankin N. G. Neznanov |
| author_facet | R. F. Nasyrova N. A. Schnaider K. O. Mironov G. A. Shipulin O. P. Dribnokhodova E. A. Golosov M. Yu. Tolmachev B. V. Andreev A. A. Kurylev L. Sh. Akhmetova О. V. Limankin N. G. Neznanov |
| author_sort | R. F. Nasyrova |
| collection | DOAJ |
| description | Schizophrenia is a socially significant mental disorder characterized by early onset and high time and financial expenditure on treatment. The basic drugs in these patients are antipsychotics that are highly effective against the positive and negative symptoms of schizophrenia, but at the same time have a wide range of adverse reactions (ARs). The clinical effect and tolerability of antipsychotics are variable and depend on the characteristics of genetically determined mechanisms (transportation, biotransformation, and elimination).The paper describes a clinical case of a female patient with schizophrenia who has been noted to be unresponsive to antipsychotic therapy for some years after the onset of the disease. After pharmacogenetic testing, she was found to be homozygous for the nonfunctional allelic variant CYP2D6*4 (1934 G>A, rs3892097), which was the reason for the complete shutdown of isoenzyme 2D6 activity and the development of ARs in the use of initial doses of antipsychotic drugs, as well as for an increase in the severity of ARs with aggravation of psycho-producing symptoms with an even slow titration of the daily dose. |
| format | Article |
| id | doaj-art-2f6b08bfa5744458934dcfc8b67f1dfd |
| institution | OA Journals |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj-art-2f6b08bfa5744458934dcfc8b67f1dfd2025-08-20T02:16:14ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422018-12-01104889310.14412/2074-2711-2018-4-88-93805Pharmacogenetics of schizophrenia in real clinical practice: a clinical caseR. F. Nasyrova0N. A. Schnaider1K. O. Mironov2G. A. Shipulin3O. P. Dribnokhodova4E. A. Golosov5M. Yu. Tolmachev6B. V. Andreev7A. A. Kurylev8L. Sh. Akhmetova9О. V. Limankin10N. G. Neznanov11V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia; P.P. Kashchenko Saint Petersburg City Mental Hospital OneV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of RussiaCentral Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-BeingCenter for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of RussiaCentral Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-BeingP.P. Kashchenko Saint Petersburg City Mental Hospital OneV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of RussiaP.P. Kashchenko Saint Petersburg City Mental Hospital One; Saint Petersburg State UniversityP.P. Kashchenko Saint Petersburg City Mental Hospital One; Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of RussiaP.P. Kashchenko Saint Petersburg City Mental Hospital OneV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia; Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaSchizophrenia is a socially significant mental disorder characterized by early onset and high time and financial expenditure on treatment. The basic drugs in these patients are antipsychotics that are highly effective against the positive and negative symptoms of schizophrenia, but at the same time have a wide range of adverse reactions (ARs). The clinical effect and tolerability of antipsychotics are variable and depend on the characteristics of genetically determined mechanisms (transportation, biotransformation, and elimination).The paper describes a clinical case of a female patient with schizophrenia who has been noted to be unresponsive to antipsychotic therapy for some years after the onset of the disease. After pharmacogenetic testing, she was found to be homozygous for the nonfunctional allelic variant CYP2D6*4 (1934 G>A, rs3892097), which was the reason for the complete shutdown of isoenzyme 2D6 activity and the development of ARs in the use of initial doses of antipsychotic drugs, as well as for an increase in the severity of ARs with aggravation of psycho-producing symptoms with an even slow titration of the daily dose.https://nnp.ima-press.net/nnp/article/view/1002pharmacogenomicspharmacogeneticsantipsychoticsschizophreniap-glycoproteincytochrome p450 |
| spellingShingle | R. F. Nasyrova N. A. Schnaider K. O. Mironov G. A. Shipulin O. P. Dribnokhodova E. A. Golosov M. Yu. Tolmachev B. V. Andreev A. A. Kurylev L. Sh. Akhmetova О. V. Limankin N. G. Neznanov Pharmacogenetics of schizophrenia in real clinical practice: a clinical case Неврология, нейропсихиатрия, психосоматика pharmacogenomics pharmacogenetics antipsychotics schizophrenia p-glycoprotein cytochrome p450 |
| title | Pharmacogenetics of schizophrenia in real clinical practice: a clinical case |
| title_full | Pharmacogenetics of schizophrenia in real clinical practice: a clinical case |
| title_fullStr | Pharmacogenetics of schizophrenia in real clinical practice: a clinical case |
| title_full_unstemmed | Pharmacogenetics of schizophrenia in real clinical practice: a clinical case |
| title_short | Pharmacogenetics of schizophrenia in real clinical practice: a clinical case |
| title_sort | pharmacogenetics of schizophrenia in real clinical practice a clinical case |
| topic | pharmacogenomics pharmacogenetics antipsychotics schizophrenia p-glycoprotein cytochrome p450 |
| url | https://nnp.ima-press.net/nnp/article/view/1002 |
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