Integrating plasma circulating protein-centered multi-omics to identify potential therapeutic targets for Parkinsonian cognitive disorders

Integrating plasma circulating protein-centered multi-omics to identify potential therapeutic targets for Parkinsonian cognitive disorders

Abstract Background Parkinson's disease (PD), the second most common neurodegenerative disease with notable clinical heterogeneity, has Parkinson disease dementia (PDD) that severely impacts patients' quality of life. As no effective treatment exists, this study aimed to find potential dru...

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Bibliographic Details
Main Authors: Tayier Tuersong, Yu Xuan Yong, Yan Chen, Pei Shan Li, Samire Shataer, Munire Shataer, Liang Ying Ma, Xin Ling Yang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Plasma circulating protein
Parkinson's disease
Mendelian randomization
Transcriptome analysis
Immune cells
Parkinson's disease dementia
Online Access:https://doi.org/10.1186/s12967-025-06541-z
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