Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare
The potential of Real-world Evidence (RWE) to provide valuable insights from Real-world Data (RWD) has drawn a lot of attention recently. This shift focuses research from controlled conditions to real-world, everyday healthcare settings. The shortcomings of conventional Randomised Controlled Trials...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2025-03-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/20744/76932_CE[Ra1]_F(SS)_QC(PS_SS)_PF1(AG_OM)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850201715454771200 |
|---|---|
| author | Sangita Jogdand Smruti Besekar Satyawan Singh Patel |
| author_facet | Sangita Jogdand Smruti Besekar Satyawan Singh Patel |
| author_sort | Sangita Jogdand |
| collection | DOAJ |
| description | The potential of Real-world Evidence (RWE) to provide valuable insights from Real-world Data (RWD) has drawn a lot of attention recently. This shift focuses research from controlled conditions to real-world, everyday healthcare settings. The shortcomings of conventional Randomised Controlled Trials (RCTs) and Experimental Controlled Trials (ECTs) have led to the emergence of Pragmatic Clinical Trials (PCTs), which emphasise real-world, everyday healthcare settings. The various studies argues that PCTs can bridge the gap between efficacy and practical application in clinical research by incorporating diverse patient groups, adaptable procedures and outcome measures relevant to daily clinical practice. Therefore, this current study highlights the potential of PCTs to connect RCTs and clinical practice by examining the concept of RWE and the tests’ distinguishing features. |
| format | Article |
| id | doaj-art-2f6786a0bc174eca869936957065dbe3 |
| institution | OA Journals |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-2f6786a0bc174eca869936957065dbe32025-08-20T02:11:57ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-03-01010410.7860/JCDR/2025/76932.20744Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current HealthcareSangita Jogdand0Smruti Besekar1Satyawan Singh Patel2Professor, Department of Pharmacology, JNMC, Datta Meghe Institute of Higher Education and Research, Sawangi, Maharashtra, India.PhD Scholar, Department of Pharmacology, JNMC, Datta Meghe Institute of Higher Education and Research, Sawangi, Maharashtra, India.Chief Cordinator, University Research, Datta Meghe Institute of Higher Education and Research, Sawangi, Maharashtra, India.The potential of Real-world Evidence (RWE) to provide valuable insights from Real-world Data (RWD) has drawn a lot of attention recently. This shift focuses research from controlled conditions to real-world, everyday healthcare settings. The shortcomings of conventional Randomised Controlled Trials (RCTs) and Experimental Controlled Trials (ECTs) have led to the emergence of Pragmatic Clinical Trials (PCTs), which emphasise real-world, everyday healthcare settings. The various studies argues that PCTs can bridge the gap between efficacy and practical application in clinical research by incorporating diverse patient groups, adaptable procedures and outcome measures relevant to daily clinical practice. Therefore, this current study highlights the potential of PCTs to connect RCTs and clinical practice by examining the concept of RWE and the tests’ distinguishing features.https://jcdr.net/articles/PDF/20744/76932_CE[Ra1]_F(SS)_QC(PS_SS)_PF1(AG_OM)_PFA(IS)_PB(AG_IS)_PN(IS).pdfclinical practiceexplanatory trialreal-world data |
| spellingShingle | Sangita Jogdand Smruti Besekar Satyawan Singh Patel Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare Journal of Clinical and Diagnostic Research clinical practice explanatory trial real-world data |
| title | Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare |
| title_full | Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare |
| title_fullStr | Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare |
| title_full_unstemmed | Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare |
| title_short | Research beyond Randomised Controlled Trial: The Importance of Pragmatic Clinical Trials for Generating Real-world Evidence in Current Healthcare |
| title_sort | research beyond randomised controlled trial the importance of pragmatic clinical trials for generating real world evidence in current healthcare |
| topic | clinical practice explanatory trial real-world data |
| url | https://jcdr.net/articles/PDF/20744/76932_CE[Ra1]_F(SS)_QC(PS_SS)_PF1(AG_OM)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
| work_keys_str_mv | AT sangitajogdand researchbeyondrandomisedcontrolledtrialtheimportanceofpragmaticclinicaltrialsforgeneratingrealworldevidenceincurrenthealthcare AT smrutibesekar researchbeyondrandomisedcontrolledtrialtheimportanceofpragmaticclinicaltrialsforgeneratingrealworldevidenceincurrenthealthcare AT satyawansinghpatel researchbeyondrandomisedcontrolledtrialtheimportanceofpragmaticclinicaltrialsforgeneratingrealworldevidenceincurrenthealthcare |