Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years
Abstract Background Obesity is a complex multisystem disease that affects almost every organ system. Studying the early determinants of obesity and implementing targeted interventions have positive implications for promoting long-term health. Therefore, this study was to evaluate the impact of mater...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12889-024-20914-x |
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| author | Ang Mao Shu-Qin Yang Ying-Juan Luo Yan Ren Xu Yan Yu-Rong Qiu Xiao Yang |
| author_facet | Ang Mao Shu-Qin Yang Ying-Juan Luo Yan Ren Xu Yan Yu-Rong Qiu Xiao Yang |
| author_sort | Ang Mao |
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| description | Abstract Background Obesity is a complex multisystem disease that affects almost every organ system. Studying the early determinants of obesity and implementing targeted interventions have positive implications for promoting long-term health. Therefore, this study was to evaluate the impact of maternal pre-pregnancy overweight or obesity, weight gain rate (WGR) during the second and third trimesters, infant birth weight (IBW) and BMI trajectory group (BMI-TG) from 0 to 2 years on overweight or obesity in preschool children. Methods A retrospective cohort analysis of data obtained from a hospital was performed using chain-mediated effects to analyze the direct and indirect effects of prepregnancy body mass index (ppBMI)on preschool children’s body mass index (pcBMI), and mediated by three variables: WGR, IBW and BMI-TG. Results We found that the effect of ppBMI and pcBMI was significantly mediated by IBW and BMI-TG. After adjusting for confounding factors, the total effect of ppBMI on pcBMI was estimated to be 0.1965 (bootstrap 95% CI: 0.1154–0.2783), the direct effect was 0.1562 (bootstrap 95% CI: 0.0750–0.2362), and the indirect effect was 0.0403 (bootstrap 95% CI: 0.0219 ~ 0.0651). The mediating effect accounted for 20.5% of the variance, indicating that 20.5% of the impact of ppBMI on pcBMI was mediated by two mediating factors: IBW and the BMI-TG. Conclusions Maternal overweight/obesity before pregnancy had a significant impact on overweight/obesity in preschool children and was mediated by two main factors: IBW and the BMI-TG. |
| format | Article |
| id | doaj-art-2f66b76a50e540b19b93be976747ed7d |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-2f66b76a50e540b19b93be976747ed7d2024-12-22T12:52:58ZengBMCBMC Public Health1471-24582024-12-0124111010.1186/s12889-024-20914-xLong-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 yearsAng Mao0Shu-Qin Yang1Ying-Juan Luo2Yan Ren3Xu Yan4Yu-Rong Qiu5Xiao Yang6Medical Record Management Office, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaMedical Record Management Office, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaPreventive health department, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaPreventive health department, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaHealth Department, Chengdu Qingyang District Maternal and Child Health and Family Planning Service CenterHealth Department, Chengdu Qingyang District Center for Disease Prevention and ControlMedical Record Management Office, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaAbstract Background Obesity is a complex multisystem disease that affects almost every organ system. Studying the early determinants of obesity and implementing targeted interventions have positive implications for promoting long-term health. Therefore, this study was to evaluate the impact of maternal pre-pregnancy overweight or obesity, weight gain rate (WGR) during the second and third trimesters, infant birth weight (IBW) and BMI trajectory group (BMI-TG) from 0 to 2 years on overweight or obesity in preschool children. Methods A retrospective cohort analysis of data obtained from a hospital was performed using chain-mediated effects to analyze the direct and indirect effects of prepregnancy body mass index (ppBMI)on preschool children’s body mass index (pcBMI), and mediated by three variables: WGR, IBW and BMI-TG. Results We found that the effect of ppBMI and pcBMI was significantly mediated by IBW and BMI-TG. After adjusting for confounding factors, the total effect of ppBMI on pcBMI was estimated to be 0.1965 (bootstrap 95% CI: 0.1154–0.2783), the direct effect was 0.1562 (bootstrap 95% CI: 0.0750–0.2362), and the indirect effect was 0.0403 (bootstrap 95% CI: 0.0219 ~ 0.0651). The mediating effect accounted for 20.5% of the variance, indicating that 20.5% of the impact of ppBMI on pcBMI was mediated by two mediating factors: IBW and the BMI-TG. Conclusions Maternal overweight/obesity before pregnancy had a significant impact on overweight/obesity in preschool children and was mediated by two main factors: IBW and the BMI-TG.https://doi.org/10.1186/s12889-024-20914-xMaternal obesityChildhood obesityRetrospective cohort studyChain intermediary effectDirect effectIndirect effect |
| spellingShingle | Ang Mao Shu-Qin Yang Ying-Juan Luo Yan Ren Xu Yan Yu-Rong Qiu Xiao Yang Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years BMC Public Health Maternal obesity Childhood obesity Retrospective cohort study Chain intermediary effect Direct effect Indirect effect |
| title | Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years |
| title_full | Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years |
| title_fullStr | Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years |
| title_full_unstemmed | Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years |
| title_short | Long-term impact of maternal pre-pregnancy BMI on the risk of overweight/obesity in preschool children: mediation by infant birth weight and BMI trajectory group from 0 to 2 years |
| title_sort | long term impact of maternal pre pregnancy bmi on the risk of overweight obesity in preschool children mediation by infant birth weight and bmi trajectory group from 0 to 2 years |
| topic | Maternal obesity Childhood obesity Retrospective cohort study Chain intermediary effect Direct effect Indirect effect |
| url | https://doi.org/10.1186/s12889-024-20914-x |
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