Pharmacological inhibition of hypoxia induced acidosis employing a CAIX inhibitor sensitizes gemcitabine resistant PDAC cells

Pharmacological inhibition of hypoxia induced acidosis employing a CAIX inhibitor sensitizes gemcitabine resistant PDAC cells

Abstract The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is attributed to tumor microenvironment driven by hypoxia regulated carbonic anhydrase IX. Our study elucidates the ability of Methazolamide, a CAIX inhibitor to sensitize resistant PDAC cells. The effect of Methazolamide alone a...

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Bibliographic Details
Main Authors: Jeevan Ghosalkar, Vinay Sonawane, Swati Achrekar, Kalpana Joshi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
PDAC
Hypoxia
HIF-1α
Carbonic anhydrase
Methazolamide
Repurposing
Online Access:https://doi.org/10.1038/s41598-025-93388-5
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