PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis

PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare but aggressive and potentially lethal hyperinflammatory syndrome characterized by pathologic immune activation and excessive production of proinflammatory cytokines leading to tissue damage and multisystem organ failure. There is an urgent...

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Main Authors: Fiona Brown-Burke, Rachel Saadey, Hsiao-Yin Charlene Mao, Paola Marra, Eric Brooks, Alexa Wandtke, Ian Hout, Sydney Leon, Archisha Sharma, Aneeq Yasin, Taylor Cash, Elshafa Hassan Ahmed, Ethan Baiocchi, Stephanie Finoti, Xiaoli Zhang, Neha Bhagwat, Kris Vaddi, Peggy Scherle, Anna Mozhenkova, Ikbale El-Ayachi, Austin D. Schenk, Shelby L. Sloan, Kaylee Whitman, JoBeth Helmig-Mason, Sheldon Steyn, Haley L. Klimaszewski, Jessica Weist, Christoph Weigel, Shirsha Koirala, Lapo Alinari, Katiri Snyder, Parvathi Ranganathan, Chia-Jo Chen, Michael B. Jordan, Robert A. Baiocchi, Polina Shindiapina
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925000357
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