Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report
This case report detailed a rare co-infection of <i>Pseudomonas asiatica</i> and <i>Enterobacter hormaechei</i> in a 9-year-old warmblood mare, leading to severe cellulitis and secondary lymphangitis following traditional hoof blood-letting therapy. The mare exhibited acute l...
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MDPI AG
2025-06-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/12/6/574 |
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| author | Xiangning Huang Renjie Deng Haoen Huang Huisheng Xie Aolei Chen |
| author_facet | Xiangning Huang Renjie Deng Haoen Huang Huisheng Xie Aolei Chen |
| author_sort | Xiangning Huang |
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| description | This case report detailed a rare co-infection of <i>Pseudomonas asiatica</i> and <i>Enterobacter hormaechei</i> in a 9-year-old warmblood mare, leading to severe cellulitis and secondary lymphangitis following traditional hoof blood-letting therapy. The mare exhibited acute limb swelling, fever, cutaneous ulceration, lymphatic dysfunction and unknown anemia. Comprehensive diagnostics, including bacterial culture, whole-genome sequencing, anti-elastin antibody (AEAb) ELISA, and diagnostic imaging, confirmed the pathogens causing cellulitis and secondary lymphangitis. AEAb levels were elevated, correlating with lymphatic degradation, while radiography and lymphangiography ruled out laminitis but identified tortuous lymphatic vessels. The treatment integrated systemic antimicrobials, anti-inflammatory therapy, combined decongestive therapy, and traditional Chinese herbal medicine, resulting in resolution of infection, improved hematological parameters, and restored athletic performance. The therapeutic regimen primarily included gentamicin, enrofloxacin, oxytetracycline, and the Wei Qi Booster. The case highlights the critical role of pathogen-directed antimicrobial selection and the potential benefits of combining conventional and holistic therapies. This report emphasizes the necessity of early, multifaceted interventions to prevent life-threatening complications in equine cellulitis–lymphangitis cases. |
| format | Article |
| id | doaj-art-2f4ca2131b284a0a817ab4b4e3e4c730 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-2f4ca2131b284a0a817ab4b4e3e4c7302025-08-20T03:29:38ZengMDPI AGVeterinary Sciences2306-73812025-06-0112657410.3390/vetsci12060574Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case ReportXiangning Huang0Renjie Deng1Haoen Huang2Huisheng Xie3Aolei Chen4College of Veterinary Medicine, South China Agricultural University, 483 Wushanlu, Guangzhou 510640, ChinaCollege of Veterinary Medicine, South China Agricultural University, 483 Wushanlu, Guangzhou 510640, ChinaCollege of Veterinary Medicine, South China Agricultural University, 483 Wushanlu, Guangzhou 510640, ChinaChi University, 9650 West Highway 318, Reddick, FL 32686, USACollege of Veterinary Medicine, South China Agricultural University, 483 Wushanlu, Guangzhou 510640, ChinaThis case report detailed a rare co-infection of <i>Pseudomonas asiatica</i> and <i>Enterobacter hormaechei</i> in a 9-year-old warmblood mare, leading to severe cellulitis and secondary lymphangitis following traditional hoof blood-letting therapy. The mare exhibited acute limb swelling, fever, cutaneous ulceration, lymphatic dysfunction and unknown anemia. Comprehensive diagnostics, including bacterial culture, whole-genome sequencing, anti-elastin antibody (AEAb) ELISA, and diagnostic imaging, confirmed the pathogens causing cellulitis and secondary lymphangitis. AEAb levels were elevated, correlating with lymphatic degradation, while radiography and lymphangiography ruled out laminitis but identified tortuous lymphatic vessels. The treatment integrated systemic antimicrobials, anti-inflammatory therapy, combined decongestive therapy, and traditional Chinese herbal medicine, resulting in resolution of infection, improved hematological parameters, and restored athletic performance. The therapeutic regimen primarily included gentamicin, enrofloxacin, oxytetracycline, and the Wei Qi Booster. The case highlights the critical role of pathogen-directed antimicrobial selection and the potential benefits of combining conventional and holistic therapies. This report emphasizes the necessity of early, multifaceted interventions to prevent life-threatening complications in equine cellulitis–lymphangitis cases.https://www.mdpi.com/2306-7381/12/6/574horselymphocutaneous infections<i>Pseudomonas asiatica</i><i>Enterobacter hormaechei</i>traditional Chinese veterinary medicine (TCVM) |
| spellingShingle | Xiangning Huang Renjie Deng Haoen Huang Huisheng Xie Aolei Chen Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report Veterinary Sciences horse lymphocutaneous infections <i>Pseudomonas asiatica</i> <i>Enterobacter hormaechei</i> traditional Chinese veterinary medicine (TCVM) |
| title | Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report |
| title_full | Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report |
| title_fullStr | Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report |
| title_full_unstemmed | Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report |
| title_short | Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report |
| title_sort | pseudomonas enterobacter co infection drives cellulitis and lymphangitis in equines a case report |
| topic | horse lymphocutaneous infections <i>Pseudomonas asiatica</i> <i>Enterobacter hormaechei</i> traditional Chinese veterinary medicine (TCVM) |
| url | https://www.mdpi.com/2306-7381/12/6/574 |
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