Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity
The numerous health benefits of olive oil are widely known, however, it also provides anti-allergic properties that have not yet been fully defined. In this study, the anti-allergic activity of olive oil was evaluated by analyzing the clinical symptoms and immune-related factors in BALB/c mice that...
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| Language: | English |
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Tsinghua University Press
2023-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002026 |
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| author | Yu Ma Ming Liu Donghui Li Jie Li Zixin Guo Yunjun Liu Shengnan Wan Yixiang Liu |
| author_facet | Yu Ma Ming Liu Donghui Li Jie Li Zixin Guo Yunjun Liu Shengnan Wan Yixiang Liu |
| author_sort | Yu Ma |
| collection | DOAJ |
| description | The numerous health benefits of olive oil are widely known, however, it also provides anti-allergic properties that have not yet been fully defined. In this study, the anti-allergic activity of olive oil was evaluated by analyzing the clinical symptoms and immune-related factors in BALB/c mice that had ingested 600 mg/(kg∙day) olive oil for two weeks prior to the evaluation. An allergy model was subsequently constructed for analysis, the results of which showed that the olive oil reduced the scores of allergic symptoms in the mice, and up-regulated the hypothermia and the decline in the immune organ index. Moreover, fewer allergy-related cytokines and reduced intestinal inflammation was discovered in the olive oil-treated group. In addition, analysis of intestinal mucosal immune-related factors revealed that the olive oil promoted the expression of intestinal tight junction proteins (Claudin-1, Occludin, and ZO-1) and IL-22, and helped maintain the integrity of the intestinal epithelial physical barrier. Increased levels of mucin 2 and β-defensin were also found in the intestinal mucus of the olive oil-treated mice. These findings suggest that the oral administration of olive oil effectively attenuated the ovalbumin-induced allergic immune response in the mice, and had a positive effect on intestinal epithelial mucosal immunity. |
| format | Article |
| id | doaj-art-2f4c9bbf2b2c487698569ee0d4a006c1 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-2f4c9bbf2b2c487698569ee0d4a006c12025-02-03T02:34:36ZengTsinghua University PressFood Science and Human Wellness2213-45302023-05-01123801808Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunityYu Ma0Ming Liu1Donghui Li2Jie Li3Zixin Guo4Yunjun Liu5Shengnan Wan6Yixiang Liu7College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaNational Food and Strategic Reserves Administration, Beijing 100083, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China; Collaborative Innovation Center of Provincial and Ministerial Co-Construction for Marine Food Deep Processing, Dalian Polytechnic University, Dalian 116034, China; Corresponding author at: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China, Fax: +86-0592-6180417.The numerous health benefits of olive oil are widely known, however, it also provides anti-allergic properties that have not yet been fully defined. In this study, the anti-allergic activity of olive oil was evaluated by analyzing the clinical symptoms and immune-related factors in BALB/c mice that had ingested 600 mg/(kg∙day) olive oil for two weeks prior to the evaluation. An allergy model was subsequently constructed for analysis, the results of which showed that the olive oil reduced the scores of allergic symptoms in the mice, and up-regulated the hypothermia and the decline in the immune organ index. Moreover, fewer allergy-related cytokines and reduced intestinal inflammation was discovered in the olive oil-treated group. In addition, analysis of intestinal mucosal immune-related factors revealed that the olive oil promoted the expression of intestinal tight junction proteins (Claudin-1, Occludin, and ZO-1) and IL-22, and helped maintain the integrity of the intestinal epithelial physical barrier. Increased levels of mucin 2 and β-defensin were also found in the intestinal mucus of the olive oil-treated mice. These findings suggest that the oral administration of olive oil effectively attenuated the ovalbumin-induced allergic immune response in the mice, and had a positive effect on intestinal epithelial mucosal immunity.http://www.sciencedirect.com/science/article/pii/S2213453022002026Olive oilOVA-induced food allergyAnti-food allergyIntestinal mucosal immunization |
| spellingShingle | Yu Ma Ming Liu Donghui Li Jie Li Zixin Guo Yunjun Liu Shengnan Wan Yixiang Liu Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity Food Science and Human Wellness Olive oil OVA-induced food allergy Anti-food allergy Intestinal mucosal immunization |
| title | Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity |
| title_full | Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity |
| title_fullStr | Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity |
| title_full_unstemmed | Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity |
| title_short | Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity |
| title_sort | olive oil ameliorates allergic response in murine ovalbumin induced food allergy by promoting intestinal mucosal immunity |
| topic | Olive oil OVA-induced food allergy Anti-food allergy Intestinal mucosal immunization |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002026 |
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