Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women
Air pollution is closely associated with the development of multiple metabolic diseases. Circadian syndrome (CircS), as an extended concept of metabolic syndrome (MetS), has been proven to be a better predictor of metabolic diseases than MetS. However, the relationship between volatile organic compo...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/13/5/328 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849718949887868928 |
|---|---|
| author | Xiaoya Sun Zhenao Zhang Jingyi Ren Huanting Pei Jie Liu Bowen Yin Chongyue Zhang Rui Wen Simeng Qiao Ziyi Wang Yuxia Ma |
| author_facet | Xiaoya Sun Zhenao Zhang Jingyi Ren Huanting Pei Jie Liu Bowen Yin Chongyue Zhang Rui Wen Simeng Qiao Ziyi Wang Yuxia Ma |
| author_sort | Xiaoya Sun |
| collection | DOAJ |
| description | Air pollution is closely associated with the development of multiple metabolic diseases. Circadian syndrome (CircS), as an extended concept of metabolic syndrome (MetS), has been proven to be a better predictor of metabolic diseases than MetS. However, the relationship between volatile organic compounds (VOCs) and CircS in pre- and postmenopausal women remains unclear. This study used data from the National Health and Nutrition Examination Survey (NHANES) 2011–2020, including 520 premenopausal women and 531 postmenopausal women. Generalized linear model (GLM), restricted cubic spline (RCS) model, subgroup analyses, and weighted quantile sum (WQS) model were used to assess the relationship between VOCs and CircS. In addition, sensitivity analyses were performed to evaluate the robustness of the results. Our findings showed that seven VOC metabolites were positively associated with the risk of CircS in postmenopausal women. In premenopausal women, only two VOC metabolites were positively associated with the risk of CircS. The WQS analysis further confirmed that VOC mixtures selected by a least absolute shrinkage and selection operator (LASSO) were significantly associated with an increased risk of CircS in postmenopausal women, with HPMMA identified as the primary contributor to the combined effect. This association was not evident in premenopausal women. Meanwhile, in postmenopausal women, individual urinary VOC metabolites and VOC mixtures were observed to be positively associated with elevated glucose and short sleep. Our results highlighted that VOC exposure was strongly associated with the occurrence of CircS in postmenopausal women. Further research is needed to confirm this conclusion. |
| format | Article |
| id | doaj-art-2f458885da294b138b455f0d4b529fd9 |
| institution | DOAJ |
| issn | 2305-6304 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-2f458885da294b138b455f0d4b529fd92025-08-20T03:12:15ZengMDPI AGToxics2305-63042025-04-0113532810.3390/toxics13050328Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal WomenXiaoya Sun0Zhenao Zhang1Jingyi Ren2Huanting Pei3Jie Liu4Bowen Yin5Chongyue Zhang6Rui Wen7Simeng Qiao8Ziyi Wang9Yuxia Ma10Hebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaHebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, ChinaAir pollution is closely associated with the development of multiple metabolic diseases. Circadian syndrome (CircS), as an extended concept of metabolic syndrome (MetS), has been proven to be a better predictor of metabolic diseases than MetS. However, the relationship between volatile organic compounds (VOCs) and CircS in pre- and postmenopausal women remains unclear. This study used data from the National Health and Nutrition Examination Survey (NHANES) 2011–2020, including 520 premenopausal women and 531 postmenopausal women. Generalized linear model (GLM), restricted cubic spline (RCS) model, subgroup analyses, and weighted quantile sum (WQS) model were used to assess the relationship between VOCs and CircS. In addition, sensitivity analyses were performed to evaluate the robustness of the results. Our findings showed that seven VOC metabolites were positively associated with the risk of CircS in postmenopausal women. In premenopausal women, only two VOC metabolites were positively associated with the risk of CircS. The WQS analysis further confirmed that VOC mixtures selected by a least absolute shrinkage and selection operator (LASSO) were significantly associated with an increased risk of CircS in postmenopausal women, with HPMMA identified as the primary contributor to the combined effect. This association was not evident in premenopausal women. Meanwhile, in postmenopausal women, individual urinary VOC metabolites and VOC mixtures were observed to be positively associated with elevated glucose and short sleep. Our results highlighted that VOC exposure was strongly associated with the occurrence of CircS in postmenopausal women. Further research is needed to confirm this conclusion.https://www.mdpi.com/2305-6304/13/5/328volatile organic compoundscircadian syndromepremenopausalpostmenopausalNHANES |
| spellingShingle | Xiaoya Sun Zhenao Zhang Jingyi Ren Huanting Pei Jie Liu Bowen Yin Chongyue Zhang Rui Wen Simeng Qiao Ziyi Wang Yuxia Ma Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women Toxics volatile organic compounds circadian syndrome premenopausal postmenopausal NHANES |
| title | Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women |
| title_full | Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women |
| title_fullStr | Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women |
| title_full_unstemmed | Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women |
| title_short | Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women |
| title_sort | association between volatile organic compounds and circadian syndrome among pre and postmenopausal women |
| topic | volatile organic compounds circadian syndrome premenopausal postmenopausal NHANES |
| url | https://www.mdpi.com/2305-6304/13/5/328 |
| work_keys_str_mv | AT xiaoyasun associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT zhenaozhang associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT jingyiren associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT huantingpei associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT jieliu associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT bowenyin associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT chongyuezhang associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT ruiwen associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT simengqiao associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT ziyiwang associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen AT yuxiama associationbetweenvolatileorganiccompoundsandcircadiansyndromeamongpreandpostmenopausalwomen |