Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review
Abstract Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications of diabetes mellitus, which is different from myocardial damage caused by coronary ischemia, hypertension, and valvular disease. DCM lacks distinct clinical manifestations in its early stages, and current therapeutic a...
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BMC
2025-06-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01773-x |
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| author | Yuting Lin Shu Yang Jinjian Guo |
| author_facet | Yuting Lin Shu Yang Jinjian Guo |
| author_sort | Yuting Lin |
| collection | DOAJ |
| description | Abstract Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications of diabetes mellitus, which is different from myocardial damage caused by coronary ischemia, hypertension, and valvular disease. DCM lacks distinct clinical manifestations in its early stages, and current therapeutic approaches primarily focus on symptomatic management. Emerging evidence indicates that even with optimized glycemic regulation, the pathophysiological progression of DCM remains unmitigated. Exploring the pathogenic mechanism of DCM is the focus and hotspot of current research. Ferroptosis, an iron-dependent form of regulatory cell death, is crucial in DCM myocardial damage. Dysfunctional antioxidant defense system, increased oxidative stress, and elevated reactive oxygen species are the key mechanisms of ferroptosis in DCM. Thus, this review innovatively takes antioxidant proteins as the entry point, and for the first time systematically summarizes the molecular mechanism of antioxidant proteins to improve DCM by regulating the ferroptosis pathway, and summarizes the therapeutic strategy of medications to enhance ferroptosis in DCM by targeting the expression of antioxidant proteins, to explore the potential targets to improve ferroptosis in DCM, to provide a new perspective for the study of delaying the progression of DCM. |
| format | Article |
| id | doaj-art-2f442a94db7e456c973a6067ce3ad2f3 |
| institution | DOAJ |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-2f442a94db7e456c973a6067ce3ad2f32025-08-20T03:10:34ZengBMCDiabetology & Metabolic Syndrome1758-59962025-06-0117111310.1186/s13098-025-01773-xAntioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature reviewYuting Lin0Shu Yang1Jinjian Guo2Department of Cardiology, The Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineThe Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineAbstract Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications of diabetes mellitus, which is different from myocardial damage caused by coronary ischemia, hypertension, and valvular disease. DCM lacks distinct clinical manifestations in its early stages, and current therapeutic approaches primarily focus on symptomatic management. Emerging evidence indicates that even with optimized glycemic regulation, the pathophysiological progression of DCM remains unmitigated. Exploring the pathogenic mechanism of DCM is the focus and hotspot of current research. Ferroptosis, an iron-dependent form of regulatory cell death, is crucial in DCM myocardial damage. Dysfunctional antioxidant defense system, increased oxidative stress, and elevated reactive oxygen species are the key mechanisms of ferroptosis in DCM. Thus, this review innovatively takes antioxidant proteins as the entry point, and for the first time systematically summarizes the molecular mechanism of antioxidant proteins to improve DCM by regulating the ferroptosis pathway, and summarizes the therapeutic strategy of medications to enhance ferroptosis in DCM by targeting the expression of antioxidant proteins, to explore the potential targets to improve ferroptosis in DCM, to provide a new perspective for the study of delaying the progression of DCM.https://doi.org/10.1186/s13098-025-01773-xDiabetic cardiomyopathyFerroptosisOxidative stressAntioxidant proteinsTherapy |
| spellingShingle | Yuting Lin Shu Yang Jinjian Guo Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review Diabetology & Metabolic Syndrome Diabetic cardiomyopathy Ferroptosis Oxidative stress Antioxidant proteins Therapy |
| title | Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review |
| title_full | Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review |
| title_fullStr | Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review |
| title_full_unstemmed | Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review |
| title_short | Antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy: a literature review |
| title_sort | antioxidant proteins can be potential targets in ameliorating ferroptosis in diabetic cardiomyopathy a literature review |
| topic | Diabetic cardiomyopathy Ferroptosis Oxidative stress Antioxidant proteins Therapy |
| url | https://doi.org/10.1186/s13098-025-01773-x |
| work_keys_str_mv | AT yutinglin antioxidantproteinscanbepotentialtargetsinamelioratingferroptosisindiabeticcardiomyopathyaliteraturereview AT shuyang antioxidantproteinscanbepotentialtargetsinamelioratingferroptosisindiabeticcardiomyopathyaliteraturereview AT jinjianguo antioxidantproteinscanbepotentialtargetsinamelioratingferroptosisindiabeticcardiomyopathyaliteraturereview |