Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis
The authors recently proposed a novel system for thermoablation—based on nanoheating—that can potentially overcome limitations associated with previously reported techniques. The aim of this study was to evaluate the therapeutic performance of the system in the ablation of hepatic tissue, the most f...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2019/6802125 |
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| _version_ | 1832564526443134976 |
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| author | Yvonne Konku John Kutor Abu Yaya Kwabena Kan-Dapaah |
| author_facet | Yvonne Konku John Kutor Abu Yaya Kwabena Kan-Dapaah |
| author_sort | Yvonne Konku |
| collection | DOAJ |
| description | The authors recently proposed a novel system for thermoablation—based on nanoheating—that can potentially overcome limitations associated with previously reported techniques. The aim of this study was to evaluate the therapeutic performance of the system in the ablation of hepatic tissue, the most frequently ablated. A model nanocomposite system, maghemite nanoparticle-filled polydimethylsiloxane, was prepared, and its magnetic properties were studied as a function of nanoparticle concentration. On the basis of measured magnetic properties, a 3D finite element method (FEM) model was used to explore the development of temperature and thermal damage in nonperfused and fully perfused tissue using alternating magnetic field (AMF) parameters that are acceptable for human use. The FEM model was tested for its validity using an analytical model. The saturation magnetization increased to about 9% of the value of pure maghemite nanoparticles over the range of volume fraction (vol. %) between 1 and 5%. Lesion sizes were shown to be greatly affected by tissue perfusion and time. FEM predictions showed good agreement with results obtained with an analytical model to within 7%. Probes fabricated with magnetic nanocomposite can potentially be used to achieve reasonable lesion sizes in hepatic tissues using human-safe AMF parameters. |
| format | Article |
| id | doaj-art-2f3ff8da485c4c87bb046d72ceab4bd5 |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-2f3ff8da485c4c87bb046d72ceab4bd52025-02-03T01:10:47ZengWileyJournal of Nanotechnology1687-95031687-95112019-01-01201910.1155/2019/68021256802125Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method AnalysisYvonne Konku0John Kutor1Abu Yaya2Kwabena Kan-Dapaah3Department of Biomedical Engineering, University of Ghana, P. O. Box LG 25, Legon, GhanaDepartment of Biomedical Engineering, University of Ghana, P. O. Box LG 25, Legon, GhanaDepartment of Materials Science and Engineering, University of Ghana, P. O. Box LG 25, Legon, GhanaDepartment of Biomedical Engineering, University of Ghana, P. O. Box LG 25, Legon, GhanaThe authors recently proposed a novel system for thermoablation—based on nanoheating—that can potentially overcome limitations associated with previously reported techniques. The aim of this study was to evaluate the therapeutic performance of the system in the ablation of hepatic tissue, the most frequently ablated. A model nanocomposite system, maghemite nanoparticle-filled polydimethylsiloxane, was prepared, and its magnetic properties were studied as a function of nanoparticle concentration. On the basis of measured magnetic properties, a 3D finite element method (FEM) model was used to explore the development of temperature and thermal damage in nonperfused and fully perfused tissue using alternating magnetic field (AMF) parameters that are acceptable for human use. The FEM model was tested for its validity using an analytical model. The saturation magnetization increased to about 9% of the value of pure maghemite nanoparticles over the range of volume fraction (vol. %) between 1 and 5%. Lesion sizes were shown to be greatly affected by tissue perfusion and time. FEM predictions showed good agreement with results obtained with an analytical model to within 7%. Probes fabricated with magnetic nanocomposite can potentially be used to achieve reasonable lesion sizes in hepatic tissues using human-safe AMF parameters.http://dx.doi.org/10.1155/2019/6802125 |
| spellingShingle | Yvonne Konku John Kutor Abu Yaya Kwabena Kan-Dapaah Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis Journal of Nanotechnology |
| title | Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis |
| title_full | Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis |
| title_fullStr | Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis |
| title_full_unstemmed | Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis |
| title_short | Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis |
| title_sort | ablation of hepatic tumors through the use of a novel magnetic nanocomposite probe magnetic characterization and finite element method analysis |
| url | http://dx.doi.org/10.1155/2019/6802125 |
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