Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects
Nectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. Overexpression of Nectin-4 has been observed in various tumors, including breast cancer, and is associated with tumor progression. Enfortumab vedotin(EV)is an antibody-drug conju...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001693 |
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| author | Yufei Wang Guangliang Li Hanying Wang Quan Qi Xian Wang Haiqi Lu |
| author_facet | Yufei Wang Guangliang Li Hanying Wang Quan Qi Xian Wang Haiqi Lu |
| author_sort | Yufei Wang |
| collection | DOAJ |
| description | Nectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. Overexpression of Nectin-4 has been observed in various tumors, including breast cancer, and is associated with tumor progression. Enfortumab vedotin(EV)is an antibody-drug conjugate (ADC) targeting Nectin-4, which has been approved by FDA for the treatment of urothelial carcinoma. Notably, Nectin-4 was also investigated as a target for breast cancer in preclinical and clinical settings. Nectin-4-targeted approaches, such as ADCs, oncolytic viruses, photothermal therapy and immunotherapy, have shown promising results in early-phase clinical trials. These therapies offer novel strategies for delivering targeted treatments to Nectin-4-expressing cancer cells, enhancing treatment efficacy and minimizing off-target effects. In conclusion, this review aims to provide an overview of the latest advances in understanding the role of Nectin-4 in breast cancer and discuss the future development prospects of Nectin-4 targeted agents. |
| format | Article |
| id | doaj-art-2f3e6b39e65f40f7a64ecbcf38bd23f7 |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-2f3e6b39e65f40f7a64ecbcf38bd23f72025-02-12T05:30:33ZengElsevierBreast1532-30802025-02-0179103838Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospectsYufei Wang0Guangliang Li1Hanying Wang2Quan Qi3Xian Wang4Haiqi Lu5Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China; Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, ChinaDepartment of Medical Oncology (Breast Cancer), Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, ChinaDepartment of Medical Oncology, Huzhou Central Hospital, Huzhou, ChinaDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China; Corresponding author.Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China; Corresponding author.Nectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. Overexpression of Nectin-4 has been observed in various tumors, including breast cancer, and is associated with tumor progression. Enfortumab vedotin(EV)is an antibody-drug conjugate (ADC) targeting Nectin-4, which has been approved by FDA for the treatment of urothelial carcinoma. Notably, Nectin-4 was also investigated as a target for breast cancer in preclinical and clinical settings. Nectin-4-targeted approaches, such as ADCs, oncolytic viruses, photothermal therapy and immunotherapy, have shown promising results in early-phase clinical trials. These therapies offer novel strategies for delivering targeted treatments to Nectin-4-expressing cancer cells, enhancing treatment efficacy and minimizing off-target effects. In conclusion, this review aims to provide an overview of the latest advances in understanding the role of Nectin-4 in breast cancer and discuss the future development prospects of Nectin-4 targeted agents.http://www.sciencedirect.com/science/article/pii/S0960977624001693Nectin-4Antibody drug conjugates (ADCs)Enfortumab vedotin (EV)Targeted therapyBreast cancer |
| spellingShingle | Yufei Wang Guangliang Li Hanying Wang Quan Qi Xian Wang Haiqi Lu Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects Breast Nectin-4 Antibody drug conjugates (ADCs) Enfortumab vedotin (EV) Targeted therapy Breast cancer |
| title | Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects |
| title_full | Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects |
| title_fullStr | Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects |
| title_full_unstemmed | Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects |
| title_short | Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects |
| title_sort | targeted therapeutic strategies for nectin 4 in breast cancer recent advances and future prospects |
| topic | Nectin-4 Antibody drug conjugates (ADCs) Enfortumab vedotin (EV) Targeted therapy Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001693 |
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