Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region
Background. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes paralysis of muscles due to degeneration of motor neurons. According to available data, the incidence of ALS in different regions of the world is from 0.6 to 3.8 per 100,000 population per year. Da...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2024-01-01
|
| Series: | Нервно-мышечные болезни |
| Subjects: | |
| Online Access: | https://nmb.abvpress.ru/jour/article/view/570 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849399752545796096 |
|---|---|
| author | E. A. Ermilov N. V. Isaeva |
| author_facet | E. A. Ermilov N. V. Isaeva |
| author_sort | E. A. Ermilov |
| collection | DOAJ |
| description | Background. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes paralysis of muscles due to degeneration of motor neurons. According to available data, the incidence of ALS in different regions of the world is from 0.6 to 3.8 per 100,000 population per year. Data obtained during the study of the epidemiology of ALS at the regional level can be used in planning medical resources, in particular, calculating the necessary respiratory equipment and funds for nutritional support.Aim. Clinical and epidemiological analysis of ALS cases registered in the Krasnoyarsk region for the period 2018–2022.Materials and methods. A clinical and epidemiological analysis of ALS cases registered in the Krasnoyarsk region from 2018 to 2022 was conducted. To do this, we used data from the specialized office of neuromuscular pathology of the Regional Clinical Hospital in Krasnoyarsk and the Krasnoyarsk Regional Medical Information and Analytical Center. Diagnosis verification was carried out in accordance with the generally accepted El Escorial and Gold Coast criteria. The functional state and degree of neurological deficit were assessed using the ALS-FRS-R scale.Results. Over the period from 2018 to 2022, 78 cases of ALS were registered. The incidence rate was 0.54 cases per 100,000 population per year. In 2022, the prevalence rate was 1.16 cases per 100 thousand population. The time from symptom onset to diagnosis of the disease ranged from 4 to 57 months, with the average time to diagnosis being 17 months. Most patients were diagnosed with ALS when their ALS-FRS-R score decreased by 7–11 points. The division of patients into groups of rapid, moderate, and slow diagnostic correlates with life expectancy. Patients who are diagnosed quickly have a higher rate of disease progression, which results in a low life expectancy.Conclusion. The creation of specialized centers will improve the diagnosis and management of patients with ALS and plan the costs of palliative care. The increase in the incidence and detection of ALS emphasizes the need to develop new approaches to the treatment and rehabilitation of patients with ALS. |
| format | Article |
| id | doaj-art-2f3ce173be604f7a8c74d279b5ed80cf |
| institution | Kabale University |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj-art-2f3ce173be604f7a8c74d279b5ed80cf2025-08-20T03:38:15ZrusABV-pressНервно-мышечные болезни2222-87212413-04432024-01-0113410.17650/2222-8721-2023-13-4-20-29361Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk regionE. A. Ermilov0N. V. Isaeva1Regional Clinical HospitalRegional Clinical Hospital; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of RussiaBackground. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes paralysis of muscles due to degeneration of motor neurons. According to available data, the incidence of ALS in different regions of the world is from 0.6 to 3.8 per 100,000 population per year. Data obtained during the study of the epidemiology of ALS at the regional level can be used in planning medical resources, in particular, calculating the necessary respiratory equipment and funds for nutritional support.Aim. Clinical and epidemiological analysis of ALS cases registered in the Krasnoyarsk region for the period 2018–2022.Materials and methods. A clinical and epidemiological analysis of ALS cases registered in the Krasnoyarsk region from 2018 to 2022 was conducted. To do this, we used data from the specialized office of neuromuscular pathology of the Regional Clinical Hospital in Krasnoyarsk and the Krasnoyarsk Regional Medical Information and Analytical Center. Diagnosis verification was carried out in accordance with the generally accepted El Escorial and Gold Coast criteria. The functional state and degree of neurological deficit were assessed using the ALS-FRS-R scale.Results. Over the period from 2018 to 2022, 78 cases of ALS were registered. The incidence rate was 0.54 cases per 100,000 population per year. In 2022, the prevalence rate was 1.16 cases per 100 thousand population. The time from symptom onset to diagnosis of the disease ranged from 4 to 57 months, with the average time to diagnosis being 17 months. Most patients were diagnosed with ALS when their ALS-FRS-R score decreased by 7–11 points. The division of patients into groups of rapid, moderate, and slow diagnostic correlates with life expectancy. Patients who are diagnosed quickly have a higher rate of disease progression, which results in a low life expectancy.Conclusion. The creation of specialized centers will improve the diagnosis and management of patients with ALS and plan the costs of palliative care. The increase in the incidence and detection of ALS emphasizes the need to develop new approaches to the treatment and rehabilitation of patients with ALS.https://nmb.abvpress.ru/jour/article/view/570amyotrophic lateral sclerosisepidemiologymorbiditylife expectancydiagnostics |
| spellingShingle | E. A. Ermilov N. V. Isaeva Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region Нервно-мышечные болезни amyotrophic lateral sclerosis epidemiology morbidity life expectancy diagnostics |
| title | Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region |
| title_full | Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region |
| title_fullStr | Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region |
| title_full_unstemmed | Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region |
| title_short | Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region |
| title_sort | epidemiology of amyotrophic lateral sclerosis in the krasnoyarsk region |
| topic | amyotrophic lateral sclerosis epidemiology morbidity life expectancy diagnostics |
| url | https://nmb.abvpress.ru/jour/article/view/570 |
| work_keys_str_mv | AT eaermilov epidemiologyofamyotrophiclateralsclerosisinthekrasnoyarskregion AT nvisaeva epidemiologyofamyotrophiclateralsclerosisinthekrasnoyarskregion |