The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve
IntroductionClinical evidence highlighting the efficacy and safety of transcatheter aortic valve replacement (TAVR) and the 2019 Food and Drug Administration (FDA) approval for TAVR in low-risk (younger) patients has created a demand for durable and long-lasting bioprosthetic heart valve (BHV) leafl...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1512961/full |
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| author | William M. L. Neethling Guenther Forster Christopher Meduri Bart Meuris Anita W. Asgar Stephanie Sellers João L. Cavalcante Vinayak Bapat Michael Reardon |
| author_facet | William M. L. Neethling Guenther Forster Christopher Meduri Bart Meuris Anita W. Asgar Stephanie Sellers João L. Cavalcante Vinayak Bapat Michael Reardon |
| author_sort | William M. L. Neethling |
| collection | DOAJ |
| description | IntroductionClinical evidence highlighting the efficacy and safety of transcatheter aortic valve replacement (TAVR) and the 2019 Food and Drug Administration (FDA) approval for TAVR in low-risk (younger) patients has created a demand for durable and long-lasting bioprosthetic heart valve (BHV) leaflet materials. Over the life of an implanted BHV mechanical stress, immunogenicity, calcification, and hemodynamic dysfunction lead to failure via structural valve deterioration (SVD). Consequently, the durability of the bioprosthetic materials selected for valve manufacture is of utmost importance.TechnologyThe ADAPT™ tissue engineering process, an anti-calcification preparation that transforms xenograft tissue (bovine pericardium) into a durable valve bioscaffold, shows significant clinical benefits in mitigating the interrelated mechanisms leading to SVD. The novel acellular, biostable and non-calcifying biomaterial has recently been molded into a single-piece 3D biomimetic valve (DurAVR™) with excellent early clinical results and the potential to meet the growing demand of durable BHVs for the treatment of aortic stenosis.DiscussionThe unique design of the DurAVR biomimetic valve in combination with the superior biostability of ADAPT tissue could advance the BHV space by providing superior performance and durability to aortic stenosis patients in need of TAVR. |
| format | Article |
| id | doaj-art-2f35f7d8aef04561ae87d23d0264e114 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-2f35f7d8aef04561ae87d23d0264e1142025-02-07T06:49:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.15129611512961The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valveWilliam M. L. Neethling0Guenther Forster1Christopher Meduri2Bart Meuris3Anita W. Asgar4Stephanie Sellers5João L. Cavalcante6Vinayak Bapat7Michael Reardon8Cardiovascular Research, Anteris Technologies Ltd, Perth, WA, AustraliaCardiovascular Research, Anteris Technologies Ltd, Perth, WA, AustraliaDepartment of Cardiology, Karolinska University Hospital, Stockholm, SwedenCardiac Surgery, University Hospitals Leuven, Leuven, BelgiumStructural Heart Program, Institut de Cardiologie de Montreal, Montreal, QC, CanadaCardiovascular Translational Laboratory, Providence Research & Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, CanadaSection of Cardiac Imaging, Allina Health Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, United StatesDepartment of Cardiac Surgery, Allina Abbott Northwestern Hospital, Minneapolis, MN, United StatesDepartment of Cardiothoracic Surgery, Houston Methodist Hospital, Houston, TX, United StatesIntroductionClinical evidence highlighting the efficacy and safety of transcatheter aortic valve replacement (TAVR) and the 2019 Food and Drug Administration (FDA) approval for TAVR in low-risk (younger) patients has created a demand for durable and long-lasting bioprosthetic heart valve (BHV) leaflet materials. Over the life of an implanted BHV mechanical stress, immunogenicity, calcification, and hemodynamic dysfunction lead to failure via structural valve deterioration (SVD). Consequently, the durability of the bioprosthetic materials selected for valve manufacture is of utmost importance.TechnologyThe ADAPT™ tissue engineering process, an anti-calcification preparation that transforms xenograft tissue (bovine pericardium) into a durable valve bioscaffold, shows significant clinical benefits in mitigating the interrelated mechanisms leading to SVD. The novel acellular, biostable and non-calcifying biomaterial has recently been molded into a single-piece 3D biomimetic valve (DurAVR™) with excellent early clinical results and the potential to meet the growing demand of durable BHVs for the treatment of aortic stenosis.DiscussionThe unique design of the DurAVR biomimetic valve in combination with the superior biostability of ADAPT tissue could advance the BHV space by providing superior performance and durability to aortic stenosis patients in need of TAVR.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1512961/fullstructural valve deteriorationcalcificationADAPTTMhemodynamicsTAVRbioprosthetic valve |
| spellingShingle | William M. L. Neethling Guenther Forster Christopher Meduri Bart Meuris Anita W. Asgar Stephanie Sellers João L. Cavalcante Vinayak Bapat Michael Reardon The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve Frontiers in Cardiovascular Medicine structural valve deterioration calcification ADAPTTM hemodynamics TAVR bioprosthetic valve |
| title | The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve |
| title_full | The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve |
| title_fullStr | The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve |
| title_full_unstemmed | The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve |
| title_short | The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve |
| title_sort | importance of tissue science and valve design in relation to durability and hemodynamics of the duravr aortic heart valve |
| topic | structural valve deterioration calcification ADAPTTM hemodynamics TAVR bioprosthetic valve |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1512961/full |
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