Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
Adequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2010-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5503 |
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| author | Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Dmitriy Nikitich Laptev Valentina Alexandrovna Peterkova |
| author_facet | Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Dmitriy Nikitich Laptev Valentina Alexandrovna Peterkova |
| author_sort | Andrey Olegovich Emel'yanov |
| collection | DOAJ |
| description | Adequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the most efficacious tool for the improvement of glycemic control.Aim. To estimate results of glycemic control in children and adolescents treated by insulin pump therapy. Materials and methods. The study included 173 patients aged 1.5-22 years having the disease for 0.5-20 years. MiniMed 508, MiniMed 712,MiniMed 722, Accu Check Spirit, Accu check D-Tron, Dana Care IIs pumps, ultrashort-acting insulins aspart and lispro were used. The patientsperformed self-control of glycemia 4-8 times during 24 hours. HbA1c was measured before and 12, 24, 36, 48 months after the onset of therapy. Thefrequency of DKA and severe hypoglycemia was recorded. Results. The HbA1c before the onset of therapy was 9.8 ?2.0% and dropped to 8.6; 8.7; 8.7; 8.9 and 9% 12, 24, 36, 48 months after it respectively.DKA was diagnosed in 20 (2.4%) and severe hypoglycemia in 5 patients. All patients in the CSII group were content with the use of the pumps, theabsence of injections and flexible day regimen. Conclusion. One year after the beginning of therapy the level of HbA1c significantly decreased. However, it increased again during a follow-up of5 years probably because of impaired compliance. This fact implies the necessity to regular repeat patient education for raising awareness of and motivationfor self-management. |
| format | Article |
| id | doaj-art-2f2f8794898d4bb7ba8873b34f651cc6 |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2010-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-2f2f8794898d4bb7ba8873b34f651cc62025-08-20T03:47:54ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782010-09-0113314314610.14341/2072-0351-55035461Prospective study of efficacy and safety of insulin pump therapy in children and adolescentsAndrey Olegovich Emel'yanov0Tamara Leonidovna Kuraeva1Dmitriy Nikitich Laptev2Valentina Alexandrovna Peterkova3Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAdequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the most efficacious tool for the improvement of glycemic control.Aim. To estimate results of glycemic control in children and adolescents treated by insulin pump therapy. Materials and methods. The study included 173 patients aged 1.5-22 years having the disease for 0.5-20 years. MiniMed 508, MiniMed 712,MiniMed 722, Accu Check Spirit, Accu check D-Tron, Dana Care IIs pumps, ultrashort-acting insulins aspart and lispro were used. The patientsperformed self-control of glycemia 4-8 times during 24 hours. HbA1c was measured before and 12, 24, 36, 48 months after the onset of therapy. Thefrequency of DKA and severe hypoglycemia was recorded. Results. The HbA1c before the onset of therapy was 9.8 ?2.0% and dropped to 8.6; 8.7; 8.7; 8.9 and 9% 12, 24, 36, 48 months after it respectively.DKA was diagnosed in 20 (2.4%) and severe hypoglycemia in 5 patients. All patients in the CSII group were content with the use of the pumps, theabsence of injections and flexible day regimen. Conclusion. One year after the beginning of therapy the level of HbA1c significantly decreased. However, it increased again during a follow-up of5 years probably because of impaired compliance. This fact implies the necessity to regular repeat patient education for raising awareness of and motivationfor self-management.https://www.dia-endojournals.ru/jour/article/view/5503type 1 diabetes mellituschildren and adolescentsinsulinotherapyinsulin pump |
| spellingShingle | Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Dmitriy Nikitich Laptev Valentina Alexandrovna Peterkova Prospective study of efficacy and safety of insulin pump therapy in children and adolescents Сахарный диабет type 1 diabetes mellitus children and adolescents insulinotherapy insulin pump |
| title | Prospective study of efficacy and safety of insulin pump therapy in children and adolescents |
| title_full | Prospective study of efficacy and safety of insulin pump therapy in children and adolescents |
| title_fullStr | Prospective study of efficacy and safety of insulin pump therapy in children and adolescents |
| title_full_unstemmed | Prospective study of efficacy and safety of insulin pump therapy in children and adolescents |
| title_short | Prospective study of efficacy and safety of insulin pump therapy in children and adolescents |
| title_sort | prospective study of efficacy and safety of insulin pump therapy in children and adolescents |
| topic | type 1 diabetes mellitus children and adolescents insulinotherapy insulin pump |
| url | https://www.dia-endojournals.ru/jour/article/view/5503 |
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