Fluorofenidone alleviates cigarette smoke exposure-induced chronic lung injury by targeting ferroptosis

Fluorofenidone alleviates cigarette smoke exposure-induced chronic lung injury by targeting ferroptosis

Abstract Chronic obstructive pulmonary disease (COPD) is a common condition that poses significant health risks to humans. Pulmonary interstitial fibrosis (PIF) often manifests in advanced stages of COPD. Fluorofenidone (AKF) has a wide range of pharmacological effects, including anti-fibrotic, anti...

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Bibliographic Details
Main Authors: Yuan Wu, Binbin Li, Yixuan Xuan, Yu Jiang, Jinping Chen, Hong Liao, Jihua Feng, Jianfeng Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Fluorofenidone
Lung injury
Lung fibrosis
Ferroptosis
NF-κB
Online Access:https://doi.org/10.1038/s41598-024-83998-w
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