The genus Nocardia as a source of new antimicrobials
Abstract The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimicrobial secondary metabolites. This review highlight...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00075-6 |
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| author | Napawit Nonthakaew Liam K. R. Sharkey Sacha J. Pidot |
| author_facet | Napawit Nonthakaew Liam K. R. Sharkey Sacha J. Pidot |
| author_sort | Napawit Nonthakaew |
| collection | DOAJ |
| description | Abstract The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimicrobial secondary metabolites. This review highlights notable examples of these compounds and explores modern approaches to unlocking their untapped biosynthetic potential. As a relatively underexplored genus, Nocardia represents a promising source for new antibiotics to combat the growing resistance crisis. |
| format | Article |
| id | doaj-art-2f2ea2caff3e45e592de5f73b332b38b |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-2f2ea2caff3e45e592de5f73b332b38b2025-01-26T12:54:18ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-01-01311710.1038/s44259-025-00075-6The genus Nocardia as a source of new antimicrobialsNapawit Nonthakaew0Liam K. R. Sharkey1Sacha J. Pidot2Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of MelbourneDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of MelbourneDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of MelbourneAbstract The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimicrobial secondary metabolites. This review highlights notable examples of these compounds and explores modern approaches to unlocking their untapped biosynthetic potential. As a relatively underexplored genus, Nocardia represents a promising source for new antibiotics to combat the growing resistance crisis.https://doi.org/10.1038/s44259-025-00075-6 |
| spellingShingle | Napawit Nonthakaew Liam K. R. Sharkey Sacha J. Pidot The genus Nocardia as a source of new antimicrobials npj Antimicrobials and Resistance |
| title | The genus Nocardia as a source of new antimicrobials |
| title_full | The genus Nocardia as a source of new antimicrobials |
| title_fullStr | The genus Nocardia as a source of new antimicrobials |
| title_full_unstemmed | The genus Nocardia as a source of new antimicrobials |
| title_short | The genus Nocardia as a source of new antimicrobials |
| title_sort | genus nocardia as a source of new antimicrobials |
| url | https://doi.org/10.1038/s44259-025-00075-6 |
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